Targeting of [alpha]v integrin identifies a core molecular pathway that regulates fibrosis in several organs

Myofibroblasts are the major source of extracellular matrix components that accumulate during tissue fibrosis, and hepatic stellate cells (HSCs) are believed to be the major source of myofibroblasts in the liver. To date, robust systems to genetically manipulate these cells have not been developed....

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Veröffentlicht in:	Nature medicine 2013-12, Vol.19 (12), p.1617
Hauptverfasser:	Henderson, Neil C, Arnold, Thomas D, Katamura, Yoshio, Giacomini, Marilyn M, Rodriguez, Juan D, Mccarty, Joseph H, Pellicoro, Antonella, Raschperger, Elisabeth, Betsholtz, Christer, Ruminski, Peter G, Griggs, David W, Prinsen, Michael J, Maher, Jacquelyn J, Iredale, John P, Lacy-hulbert, Adam, Adams, Ralf H, Sheppard, Dean
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical research Liver Liver diseases Lung diseases Organs Pharmaceutical sciences Studies
Online-Zugang:	Volltext
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