The effects of ergot alkaloids on the breeding stallion reproductive system
Summary Reasons for performing study Ergot alkaloids cause a range of pathological conditions in mares. There is no evaluation of the effects of ergot alkaloids from endophyte‐infected tall fescue on the stallion breeding soundness examination spermiogram. Objectives The objective of this study was...
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| Veröffentlicht in: | Equine veterinary journal 2013-12, Vol.45 (S45), p.44-47 |
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| container_title | Equine veterinary journal |
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| creator | Fayrer-Hosken, R. A. Hill, N. S. Heusner, G. L. Traylor-Wiggins, W. Turner, K. |
| description | Summary
Reasons for performing study
Ergot alkaloids cause a range of pathological conditions in mares. There is no evaluation of the effects of ergot alkaloids from endophyte‐infected tall fescue on the stallion breeding soundness examination spermiogram.
Objectives
The objective of this study was to investigate the effect of ergot alkaloids from endophyte‐infected tall fescue on the stallion's reproductive functions.
Study design
Crossover toxicology experiment.
Methods
Six stallions were fed either toxic endophyte‐infected tall fescue seed or a nontoxic endophyte tall fescue seed (Flecha AR‐542, MaxQ). The fescue seed content was compounded at 45% of a grain diet and the stallions were fed the grain diet at 1% of their body weight. The stallions were fed the diet for 70 days, then rested for at least 70 days (no fescue seed) and then fed fescue seed for a second 70 days. At regular intervals blood sampling and a breeding soundness examination were performed.
Results
The mean time to maximal systemic toxicity was 8.33 h after starting toxic seed ingestion with a mean toxicity level of 49.98 ng alkaloid/mg creatinine. After cessation of feeding toxic seed, the systemic alkaloid concentration fell to control levels within 48 h. There were no significant changes in sperm motility, sperm concentration, sperm cell morphology, total number of sperm cells, number of breeding doses, testicular volume, baseline and human chorionic gonadotropin stimulated testosterone levels. There were no changes in core body temperature and superficial scrotal temperature. The ejaculate from stallions consuming endophyte‐infected tall fescue seed had significantly lower gel‐free volume (47.5 ± 4.1 ml) than stallions consuming nontoxic endophyte tall fescue seed (62.8 + 4.3 ml, P |
| doi_str_mv | 10.1111/evj.12164 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1464858901</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3145797261</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4264-6cd9ae3271bc3fcd9e01a072f9c4a1538910bf02cb56a19c4a072afc698703553</originalsourceid><addsrcrecordid>eNp1kEtPAjEUhRujEUQX_gEziSsXA33Na2kI4oPoQoTETdPp3OLAwGA7g_LvLQ6ys5v2nn733JuD0CXBXeJODzbzLqEk5EeoTTGnPmM4PEZt9wx8J_MWOrN2jjFjlNNT1KKcYc4xa6On8Qd4oDWoynql9sDMysqTxUIWZZ45aeVVjkgNQJavZp6tZFHkTjWwNmVWqyrfgGe3toLlOTrRsrBwsb876O1uMO7f-6OX4UP_duQrTkPuhypLJDAakVQx7QrAROKI6kRxSQIWJwSnGlOVBqEkO9F9Sq3CJI4wCwLWQdeNr9vgswZbiXlZm5UbKQgPeRzECSaOumkoZUprDWixNvlSmq0gWOxiEy428RubY6_2jnW6hOxA_uXkgF4DfOUFbP93EoPJ45-l33TkLprvQ4c0CxFGLArE9HkoMH9nyfQ1EBP2A5QwhQs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1464858901</pqid></control><display><type>article</type><title>The effects of ergot alkaloids on the breeding stallion reproductive system</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Fayrer-Hosken, R. A. ; Hill, N. S. ; Heusner, G. L. ; Traylor-Wiggins, W. ; Turner, K.</creator><creatorcontrib>Fayrer-Hosken, R. A. ; Hill, N. S. ; Heusner, G. L. ; Traylor-Wiggins, W. ; Turner, K.</creatorcontrib><description>Summary
Reasons for performing study
Ergot alkaloids cause a range of pathological conditions in mares. There is no evaluation of the effects of ergot alkaloids from endophyte‐infected tall fescue on the stallion breeding soundness examination spermiogram.
Objectives
The objective of this study was to investigate the effect of ergot alkaloids from endophyte‐infected tall fescue on the stallion's reproductive functions.
Study design
Crossover toxicology experiment.
Methods
Six stallions were fed either toxic endophyte‐infected tall fescue seed or a nontoxic endophyte tall fescue seed (Flecha AR‐542, MaxQ). The fescue seed content was compounded at 45% of a grain diet and the stallions were fed the grain diet at 1% of their body weight. The stallions were fed the diet for 70 days, then rested for at least 70 days (no fescue seed) and then fed fescue seed for a second 70 days. At regular intervals blood sampling and a breeding soundness examination were performed.
Results
The mean time to maximal systemic toxicity was 8.33 h after starting toxic seed ingestion with a mean toxicity level of 49.98 ng alkaloid/mg creatinine. After cessation of feeding toxic seed, the systemic alkaloid concentration fell to control levels within 48 h. There were no significant changes in sperm motility, sperm concentration, sperm cell morphology, total number of sperm cells, number of breeding doses, testicular volume, baseline and human chorionic gonadotropin stimulated testosterone levels. There were no changes in core body temperature and superficial scrotal temperature. The ejaculate from stallions consuming endophyte‐infected tall fescue seed had significantly lower gel‐free volume (47.5 ± 4.1 ml) than stallions consuming nontoxic endophyte tall fescue seed (62.8 + 4.3 ml, P<0.01).
Conclusion
Ergot alkaloids decreased the gel‐free volume of stallions consuming high levels of ergot alkaloids but statistically significant effects on the spermiogram of adult breeding stallions were not found.</description><identifier>ISSN: 0425-1644</identifier><identifier>EISSN: 2042-3306</identifier><identifier>DOI: 10.1111/evj.12164</identifier><identifier>PMID: 24304403</identifier><identifier>CODEN: EQVJAI</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animal Feed ; Animals ; Breeding ; Diet - veterinary ; endophyte ; Ergot Alkaloids ; horse ; Horses ; Male ; Poaceae ; Seeds ; semen parameters ; spermiogram ; tall fescue</subject><ispartof>Equine veterinary journal, 2013-12, Vol.45 (S45), p.44-47</ispartof><rights>2013 EVJ Ltd</rights><rights>2013 EVJ Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4264-6cd9ae3271bc3fcd9e01a072f9c4a1538910bf02cb56a19c4a072afc698703553</citedby><cites>FETCH-LOGICAL-c4264-6cd9ae3271bc3fcd9e01a072f9c4a1538910bf02cb56a19c4a072afc698703553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fevj.12164$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fevj.12164$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24304403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fayrer-Hosken, R. A.</creatorcontrib><creatorcontrib>Hill, N. S.</creatorcontrib><creatorcontrib>Heusner, G. L.</creatorcontrib><creatorcontrib>Traylor-Wiggins, W.</creatorcontrib><creatorcontrib>Turner, K.</creatorcontrib><title>The effects of ergot alkaloids on the breeding stallion reproductive system</title><title>Equine veterinary journal</title><addtitle>Equine Vet J</addtitle><description>Summary
Reasons for performing study
Ergot alkaloids cause a range of pathological conditions in mares. There is no evaluation of the effects of ergot alkaloids from endophyte‐infected tall fescue on the stallion breeding soundness examination spermiogram.
Objectives
The objective of this study was to investigate the effect of ergot alkaloids from endophyte‐infected tall fescue on the stallion's reproductive functions.
Study design
Crossover toxicology experiment.
Methods
Six stallions were fed either toxic endophyte‐infected tall fescue seed or a nontoxic endophyte tall fescue seed (Flecha AR‐542, MaxQ). The fescue seed content was compounded at 45% of a grain diet and the stallions were fed the grain diet at 1% of their body weight. The stallions were fed the diet for 70 days, then rested for at least 70 days (no fescue seed) and then fed fescue seed for a second 70 days. At regular intervals blood sampling and a breeding soundness examination were performed.
Results
The mean time to maximal systemic toxicity was 8.33 h after starting toxic seed ingestion with a mean toxicity level of 49.98 ng alkaloid/mg creatinine. After cessation of feeding toxic seed, the systemic alkaloid concentration fell to control levels within 48 h. There were no significant changes in sperm motility, sperm concentration, sperm cell morphology, total number of sperm cells, number of breeding doses, testicular volume, baseline and human chorionic gonadotropin stimulated testosterone levels. There were no changes in core body temperature and superficial scrotal temperature. The ejaculate from stallions consuming endophyte‐infected tall fescue seed had significantly lower gel‐free volume (47.5 ± 4.1 ml) than stallions consuming nontoxic endophyte tall fescue seed (62.8 + 4.3 ml, P<0.01).
Conclusion
Ergot alkaloids decreased the gel‐free volume of stallions consuming high levels of ergot alkaloids but statistically significant effects on the spermiogram of adult breeding stallions were not found.</description><subject>Animal Feed</subject><subject>Animals</subject><subject>Breeding</subject><subject>Diet - veterinary</subject><subject>endophyte</subject><subject>Ergot Alkaloids</subject><subject>horse</subject><subject>Horses</subject><subject>Male</subject><subject>Poaceae</subject><subject>Seeds</subject><subject>semen parameters</subject><subject>spermiogram</subject><subject>tall fescue</subject><issn>0425-1644</issn><issn>2042-3306</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtPAjEUhRujEUQX_gEziSsXA33Na2kI4oPoQoTETdPp3OLAwGA7g_LvLQ6ys5v2nn733JuD0CXBXeJODzbzLqEk5EeoTTGnPmM4PEZt9wx8J_MWOrN2jjFjlNNT1KKcYc4xa6On8Qd4oDWoynql9sDMysqTxUIWZZ45aeVVjkgNQJavZp6tZFHkTjWwNmVWqyrfgGe3toLlOTrRsrBwsb876O1uMO7f-6OX4UP_duQrTkPuhypLJDAakVQx7QrAROKI6kRxSQIWJwSnGlOVBqEkO9F9Sq3CJI4wCwLWQdeNr9vgswZbiXlZm5UbKQgPeRzECSaOumkoZUprDWixNvlSmq0gWOxiEy428RubY6_2jnW6hOxA_uXkgF4DfOUFbP93EoPJ45-l33TkLprvQ4c0CxFGLArE9HkoMH9nyfQ1EBP2A5QwhQs</recordid><startdate>201312</startdate><enddate>201312</enddate><creator>Fayrer-Hosken, R. A.</creator><creator>Hill, N. S.</creator><creator>Heusner, G. L.</creator><creator>Traylor-Wiggins, W.</creator><creator>Turner, K.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>201312</creationdate><title>The effects of ergot alkaloids on the breeding stallion reproductive system</title><author>Fayrer-Hosken, R. A. ; Hill, N. S. ; Heusner, G. L. ; Traylor-Wiggins, W. ; Turner, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4264-6cd9ae3271bc3fcd9e01a072f9c4a1538910bf02cb56a19c4a072afc698703553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animal Feed</topic><topic>Animals</topic><topic>Breeding</topic><topic>Diet - veterinary</topic><topic>endophyte</topic><topic>Ergot Alkaloids</topic><topic>horse</topic><topic>Horses</topic><topic>Male</topic><topic>Poaceae</topic><topic>Seeds</topic><topic>semen parameters</topic><topic>spermiogram</topic><topic>tall fescue</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fayrer-Hosken, R. A.</creatorcontrib><creatorcontrib>Hill, N. S.</creatorcontrib><creatorcontrib>Heusner, G. L.</creatorcontrib><creatorcontrib>Traylor-Wiggins, W.</creatorcontrib><creatorcontrib>Turner, K.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Equine veterinary journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fayrer-Hosken, R. A.</au><au>Hill, N. S.</au><au>Heusner, G. L.</au><au>Traylor-Wiggins, W.</au><au>Turner, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of ergot alkaloids on the breeding stallion reproductive system</atitle><jtitle>Equine veterinary journal</jtitle><addtitle>Equine Vet J</addtitle><date>2013-12</date><risdate>2013</risdate><volume>45</volume><issue>S45</issue><spage>44</spage><epage>47</epage><pages>44-47</pages><issn>0425-1644</issn><eissn>2042-3306</eissn><coden>EQVJAI</coden><abstract>Summary
Reasons for performing study
Ergot alkaloids cause a range of pathological conditions in mares. There is no evaluation of the effects of ergot alkaloids from endophyte‐infected tall fescue on the stallion breeding soundness examination spermiogram.
Objectives
The objective of this study was to investigate the effect of ergot alkaloids from endophyte‐infected tall fescue on the stallion's reproductive functions.
Study design
Crossover toxicology experiment.
Methods
Six stallions were fed either toxic endophyte‐infected tall fescue seed or a nontoxic endophyte tall fescue seed (Flecha AR‐542, MaxQ). The fescue seed content was compounded at 45% of a grain diet and the stallions were fed the grain diet at 1% of their body weight. The stallions were fed the diet for 70 days, then rested for at least 70 days (no fescue seed) and then fed fescue seed for a second 70 days. At regular intervals blood sampling and a breeding soundness examination were performed.
Results
The mean time to maximal systemic toxicity was 8.33 h after starting toxic seed ingestion with a mean toxicity level of 49.98 ng alkaloid/mg creatinine. After cessation of feeding toxic seed, the systemic alkaloid concentration fell to control levels within 48 h. There were no significant changes in sperm motility, sperm concentration, sperm cell morphology, total number of sperm cells, number of breeding doses, testicular volume, baseline and human chorionic gonadotropin stimulated testosterone levels. There were no changes in core body temperature and superficial scrotal temperature. The ejaculate from stallions consuming endophyte‐infected tall fescue seed had significantly lower gel‐free volume (47.5 ± 4.1 ml) than stallions consuming nontoxic endophyte tall fescue seed (62.8 + 4.3 ml, P<0.01).
Conclusion
Ergot alkaloids decreased the gel‐free volume of stallions consuming high levels of ergot alkaloids but statistically significant effects on the spermiogram of adult breeding stallions were not found.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24304403</pmid><doi>10.1111/evj.12164</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animal Feed Animals Breeding Diet - veterinary endophyte Ergot Alkaloids horse Horses Male Poaceae Seeds semen parameters spermiogram tall fescue |
| title | The effects of ergot alkaloids on the breeding stallion reproductive system |
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