Potent Inhibitors of Phosphatidylinositol3 (PI3) Kinase that have Antiproliferative Activity Only When Delivered as Prodrug Forms

Prodrugs for PI3K: A series of substituted analogues of the phosphatidylinositol 3 kinase (PI3K) inhibitor LY294002 were prepared and found to potently inhibit the isolated enzyme but not MCF7 cell proliferation. Two tetrazolyl-substituted analogues were further derivatized as prodrugs resulting in...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	ChemMedChem 2013-06, Vol.8 (6), p.914
Hauptverfasser:	O'Brien, Nathan J, Amran, Syazwani, Medan, Jelena, Cleary, Ben, Deady, Leslie W, Jennings, Ian G, Thompson, Philip E, Abbott, Belinda M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!