Regional variability of imaging biomarkers in autosomal dominant Alzheimer’s disease

Major imaging biomarkers of Alzheimer’s disease include amyloid deposition [imaged with [ ¹¹C]Pittsburgh compound B (PiB) PET], altered glucose metabolism (imaged with [ ¹⁸F]fluro-deoxyglucose PET), and structural atrophy (imaged by MRI). Recently we published the initial subset of imaging findings...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-11, Vol.110 (47), p.E4502-E4509
Hauptverfasser:	Benzinger, Tammie L S, Blazey, Tyler, Jack, Jr, Clifford R, Koeppe, Robert A, Su, Yi, Xiong, Chengjie, Raichle, Marcus E, Snyder, Abraham Z, Ances, Beau M, Bateman, Randall J, Cairns, Nigel J, Fagan, Anne M, Goate, Alison, Marcus, Daniel S, Aisen, Paul S, Christensen, Jon J, Ercole, Lindsay, Hornbeck, Russ C, Farrar, Angela M, Aldea, Patricia, Jasielec, Mateusz S, Owen, Christopher J, Xie, Xianyun, Mayeux, Richard, Brickman, Adam, McDade, Eric, Klunk, William, Mathis, Chester A, Ringman, John, Thompson, Paul M, Ghetti, Bernardino, Saykin, Andrew J, Sperling, Reisa A, Johnson, Keith A, Salloway, Stephen, Correia, Stephen, Schofield, Peter R, Masters, Colin L, Rowe, Christopher, Villemagne, Victor L, Martins, Ralph, Ourselin, Sebastien, Rossor, Martin N, Fox, Nick C, Cash, David M, Weiner, Michael W, Holtzman, David M, Buckles, Virginia D, Moulder, Krista, Morris, John C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age of Onset Alzheimer disease Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease amyloid Aniline Compounds - metabolism atrophy Biological Sciences Biomarkers Biomarkers - metabolism Brain - metabolism Brain - pathology Carbon Radioisotopes - metabolism Cohort Studies Female Fluorodeoxyglucose F18 - metabolism Genes, Dominant - genetics Glucose hippocampus Humans image analysis magnetic resonance imaging Magnetic Resonance Imaging - methods Male Metabolism Middle Aged Models, Biological Mutation PNAS Plus Positron-Emission Tomography - methods Regression Analysis Thiazoles - metabolism Time Factors
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