Phosphorylation of FOXO3a by PI3K/Akt pathway in HK-2 renal proximal tubular epithelial cells exposed to cadmium

We examined the effects of cadmium chloride (CdCl 2 ) exposure on the phosphorylation and function of the forkhead box class O (FOXO) transcription factor FOXO3a in HK-2 human renal proximal tubular cells. Phosphorylation of FOXO3a (at Thr32 and Ser253) and its upstream kinase, Akt (at Thr308 and Se...

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Veröffentlicht in:	Archives of toxicology 2013-12, Vol.87 (12), p.2119-2127
Hauptverfasser:	Fujiki, Kota, Inamura, Hisako, Matsuoka, Masato
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Blotting, Western Cadmium Cadmium Chloride - toxicity Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Cell Count Cell Line Cell Nucleus - drug effects Cell Nucleus - metabolism Cellular biology Cytoplasm - drug effects Cytoplasm - metabolism Environmental Health Epithelial Cells - drug effects Epithelial Cells - metabolism Forkhead Box Protein O3 Forkhead Transcription Factors - metabolism Humans Inorganic Compounds Kidney Tubules, Proximal - cytology Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - metabolism MAP Kinase Signaling System - drug effects Mitogen-Activated Protein Kinases - metabolism Nucleosomes - drug effects Occupational Medicine/Industrial Medicine p38 Mitogen-Activated Protein Kinases - metabolism Pharmacology/Toxicology Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Receptor, Epidermal Growth Factor - metabolism Receptor, IGF Type 1 - genetics Receptor, IGF Type 1 - metabolism RNA, Small Interfering Signal transduction Toxicity
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