1,25-Dihydroxy vitamin D and coronary microvascular function
Purpose The active form of vitamin D (1,25(OH) 2 D) contributes to blood flow regulation in skeletal muscle. The aim of the present study was to determine whether this hormone also modulates coronary physiology, and thus whether abnormalities in its bioavailability contribute to excess cardiovascula...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2013, Vol.40 (2), p.280-289 |
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| creator | Capitanio, Selene Sambuceti, Gianmario Giusti, Massimo Morbelli, Silvia Murialdo, Giovanni Garibotto, Giacomo Vera, Lara Ameri, Pietro Repetto, Barbara Naseri, Mehrdad Bossert, Irene Verardi, Maria Teresa Massollo, Michela Marini, Cecilia |
| description | Purpose
The active form of vitamin D (1,25(OH)
2
D) contributes to blood flow regulation in skeletal muscle. The aim of the present study was to determine whether this hormone also modulates coronary physiology, and thus whether abnormalities in its bioavailability contribute to excess cardiovascular risk in patients with disorders of mineral metabolism.
Methods
As a clinical model of the wide variability in 1,25(OH)
2
D bioavailability, we studied 23 patients (62 ± 8 years) with suspected primary hyperparathyroidism referred for myocardial perfusion imaging because of atypical chest pain and at least one cardiovascular risk factor. Dipyridamole and baseline myocardial blood flow indexes were assessed on G-SPECT imaging of
99m
Tc-tetrofosmin, with normalization of the myocardial count rate to the corresponding first-transit counts in the pulmonary artery. Coronary flow reserve (CFR) was defined as the ratio between dipyridamole and baseline myocardial blood flow indexes. In all patients, parathyroid hormone, 25-hydroxy vitamin D (25(OH)D) and 1,25(OH)
2
D serum levels were determined.
Results
Primary hyperparathyroidism was eventually diagnosed in 15 of the 23 patients. The mean 25(OH)D concentration was relatively low (21 ± 10 ng/mL) while the concentrations of 1,25(OH)
2
D varied widely but within the normal range (mean 95 ± 61 pmol/L). No patient showed reversible perfusion defects on G-SPECT. CFR was not correlated with either the serum concentration of 25(OH)D nor that of parathyroid hormone, but was strictly correlated with the serum level of 1,25(OH)
2
D (
R
= 0.8,
p
|
| doi_str_mv | 10.1007/s00259-012-2271-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1461756531</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3137747671</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-14b87615c0bd7fe9efa2cce20408fa92e196acc1b91e13c5fe78a360536296f93</originalsourceid><addsrcrecordid>eNp1kM1OwzAQhC0EoqXwAFxQJK4Ydp06jiUuqOVPqsQFzpbj2JCqSYqdVPTtcZWCuHDalXZmdvQRco5wjQDiJgAwLikgo4wJpHBAxpihpAJyefi7CxiRkxCWAJizXB6TEUuRowQ5Jrd4xTidVx_b0rdf22RTdbqummSe6KZMTOvbRvttUlfGtxsdTL_SPnF9Y7qqbU7JkdOrYM_2c0LeHu5fZ0908fL4PLtbUJMK1lGcFrnIkBsoSuGstE4zYyyDKeROS2ZRZtoYLCRaTA13VuQ6zYCnGZOZk-mEXA65a99-9jZ0atn2vokvFU4zFDzjKUYVDqpYNQRvnVr7qo7tFYLa8VIDLxV5qR0vBdFzsU_ui9qWv44fQFHABkGIp-bd-j-v_039BjnWdBE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1461756531</pqid></control><display><type>article</type><title>1,25-Dihydroxy vitamin D and coronary microvascular function</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Capitanio, Selene ; Sambuceti, Gianmario ; Giusti, Massimo ; Morbelli, Silvia ; Murialdo, Giovanni ; Garibotto, Giacomo ; Vera, Lara ; Ameri, Pietro ; Repetto, Barbara ; Naseri, Mehrdad ; Bossert, Irene ; Verardi, Maria Teresa ; Massollo, Michela ; Marini, Cecilia</creator><creatorcontrib>Capitanio, Selene ; Sambuceti, Gianmario ; Giusti, Massimo ; Morbelli, Silvia ; Murialdo, Giovanni ; Garibotto, Giacomo ; Vera, Lara ; Ameri, Pietro ; Repetto, Barbara ; Naseri, Mehrdad ; Bossert, Irene ; Verardi, Maria Teresa ; Massollo, Michela ; Marini, Cecilia</creatorcontrib><description>Purpose
The active form of vitamin D (1,25(OH)
2
D) contributes to blood flow regulation in skeletal muscle. The aim of the present study was to determine whether this hormone also modulates coronary physiology, and thus whether abnormalities in its bioavailability contribute to excess cardiovascular risk in patients with disorders of mineral metabolism.
Methods
As a clinical model of the wide variability in 1,25(OH)
2
D bioavailability, we studied 23 patients (62 ± 8 years) with suspected primary hyperparathyroidism referred for myocardial perfusion imaging because of atypical chest pain and at least one cardiovascular risk factor. Dipyridamole and baseline myocardial blood flow indexes were assessed on G-SPECT imaging of
99m
Tc-tetrofosmin, with normalization of the myocardial count rate to the corresponding first-transit counts in the pulmonary artery. Coronary flow reserve (CFR) was defined as the ratio between dipyridamole and baseline myocardial blood flow indexes. In all patients, parathyroid hormone, 25-hydroxy vitamin D (25(OH)D) and 1,25(OH)
2
D serum levels were determined.
Results
Primary hyperparathyroidism was eventually diagnosed in 15 of the 23 patients. The mean 25(OH)D concentration was relatively low (21 ± 10 ng/mL) while the concentrations of 1,25(OH)
2
D varied widely but within the normal range (mean 95 ± 61 pmol/L). No patient showed reversible perfusion defects on G-SPECT. CFR was not correlated with either the serum concentration of 25(OH)D nor that of parathyroid hormone, but was strictly correlated with the serum level of 1,25(OH)
2
D (
R
= 0.8,
p
< 0.01). Moreover, patients with a 1,25(OH)
2
D concentration below the median value (86 pmol/L) had markedly lower CFR than the other patients (1.48 ± 0.40 vs. 2.51 ± 0.63, respectively;
p
< 0.001).
Conclusion
Bioavailable 1,25(OH)
2
D modulates coronary microvascular function. This effect might contribute to the high cardiovascular risk of conditions characterized by chronic reduction in bioavailability of this hormone.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-012-2271-0</identifier><identifier>PMID: 23151909</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Aged ; Biological Availability ; Cardiology ; Cardiovascular disease ; Cardiovascular Diseases - metabolism ; Coronary Circulation ; Electrocardiography - methods ; Female ; Humans ; Hyperparathyroidism - metabolism ; Imaging ; Male ; Medical imaging ; Medicine ; Medicine & Public Health ; Microcirculation ; Middle Aged ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - physiology ; Myocardium - pathology ; Nuclear Medicine ; Oncology ; Organophosphorus Compounds - pharmacology ; Organotechnetium Compounds - pharmacology ; Original Article ; Orthopedics ; Perfusion ; Pulmonary Artery - metabolism ; Radiology ; Risk ; Risk Factors ; Tomography, Emission-Computed, Single-Photon - methods ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - metabolism</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2013, Vol.40 (2), p.280-289</ispartof><rights>Springer-Verlag Berlin Heidelberg 2012</rights><rights>Springer-Verlag Berlin Heidelberg 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-14b87615c0bd7fe9efa2cce20408fa92e196acc1b91e13c5fe78a360536296f93</citedby><cites>FETCH-LOGICAL-c372t-14b87615c0bd7fe9efa2cce20408fa92e196acc1b91e13c5fe78a360536296f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00259-012-2271-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00259-012-2271-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23151909$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Capitanio, Selene</creatorcontrib><creatorcontrib>Sambuceti, Gianmario</creatorcontrib><creatorcontrib>Giusti, Massimo</creatorcontrib><creatorcontrib>Morbelli, Silvia</creatorcontrib><creatorcontrib>Murialdo, Giovanni</creatorcontrib><creatorcontrib>Garibotto, Giacomo</creatorcontrib><creatorcontrib>Vera, Lara</creatorcontrib><creatorcontrib>Ameri, Pietro</creatorcontrib><creatorcontrib>Repetto, Barbara</creatorcontrib><creatorcontrib>Naseri, Mehrdad</creatorcontrib><creatorcontrib>Bossert, Irene</creatorcontrib><creatorcontrib>Verardi, Maria Teresa</creatorcontrib><creatorcontrib>Massollo, Michela</creatorcontrib><creatorcontrib>Marini, Cecilia</creatorcontrib><title>1,25-Dihydroxy vitamin D and coronary microvascular function</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Purpose
The active form of vitamin D (1,25(OH)
2
D) contributes to blood flow regulation in skeletal muscle. The aim of the present study was to determine whether this hormone also modulates coronary physiology, and thus whether abnormalities in its bioavailability contribute to excess cardiovascular risk in patients with disorders of mineral metabolism.
Methods
As a clinical model of the wide variability in 1,25(OH)
2
D bioavailability, we studied 23 patients (62 ± 8 years) with suspected primary hyperparathyroidism referred for myocardial perfusion imaging because of atypical chest pain and at least one cardiovascular risk factor. Dipyridamole and baseline myocardial blood flow indexes were assessed on G-SPECT imaging of
99m
Tc-tetrofosmin, with normalization of the myocardial count rate to the corresponding first-transit counts in the pulmonary artery. Coronary flow reserve (CFR) was defined as the ratio between dipyridamole and baseline myocardial blood flow indexes. In all patients, parathyroid hormone, 25-hydroxy vitamin D (25(OH)D) and 1,25(OH)
2
D serum levels were determined.
Results
Primary hyperparathyroidism was eventually diagnosed in 15 of the 23 patients. The mean 25(OH)D concentration was relatively low (21 ± 10 ng/mL) while the concentrations of 1,25(OH)
2
D varied widely but within the normal range (mean 95 ± 61 pmol/L). No patient showed reversible perfusion defects on G-SPECT. CFR was not correlated with either the serum concentration of 25(OH)D nor that of parathyroid hormone, but was strictly correlated with the serum level of 1,25(OH)
2
D (
R
= 0.8,
p
< 0.01). Moreover, patients with a 1,25(OH)
2
D concentration below the median value (86 pmol/L) had markedly lower CFR than the other patients (1.48 ± 0.40 vs. 2.51 ± 0.63, respectively;
p
< 0.001).
Conclusion
Bioavailable 1,25(OH)
2
D modulates coronary microvascular function. This effect might contribute to the high cardiovascular risk of conditions characterized by chronic reduction in bioavailability of this hormone.</description><subject>Aged</subject><subject>Biological Availability</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - metabolism</subject><subject>Coronary Circulation</subject><subject>Electrocardiography - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperparathyroidism - metabolism</subject><subject>Imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microcirculation</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - physiology</subject><subject>Myocardium - pathology</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Organophosphorus Compounds - pharmacology</subject><subject>Organotechnetium Compounds - pharmacology</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Perfusion</subject><subject>Pulmonary Artery - metabolism</subject><subject>Radiology</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Tomography, Emission-Computed, Single-Photon - methods</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - metabolism</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kM1OwzAQhC0EoqXwAFxQJK4Ydp06jiUuqOVPqsQFzpbj2JCqSYqdVPTtcZWCuHDalXZmdvQRco5wjQDiJgAwLikgo4wJpHBAxpihpAJyefi7CxiRkxCWAJizXB6TEUuRowQ5Jrd4xTidVx_b0rdf22RTdbqummSe6KZMTOvbRvttUlfGtxsdTL_SPnF9Y7qqbU7JkdOrYM_2c0LeHu5fZ0908fL4PLtbUJMK1lGcFrnIkBsoSuGstE4zYyyDKeROS2ZRZtoYLCRaTA13VuQ6zYCnGZOZk-mEXA65a99-9jZ0atn2vokvFU4zFDzjKUYVDqpYNQRvnVr7qo7tFYLa8VIDLxV5qR0vBdFzsU_ui9qWv44fQFHABkGIp-bd-j-v_039BjnWdBE</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Capitanio, Selene</creator><creator>Sambuceti, Gianmario</creator><creator>Giusti, Massimo</creator><creator>Morbelli, Silvia</creator><creator>Murialdo, Giovanni</creator><creator>Garibotto, Giacomo</creator><creator>Vera, Lara</creator><creator>Ameri, Pietro</creator><creator>Repetto, Barbara</creator><creator>Naseri, Mehrdad</creator><creator>Bossert, Irene</creator><creator>Verardi, Maria Teresa</creator><creator>Massollo, Michela</creator><creator>Marini, Cecilia</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>2013</creationdate><title>1,25-Dihydroxy vitamin D and coronary microvascular function</title><author>Capitanio, Selene ; Sambuceti, Gianmario ; Giusti, Massimo ; Morbelli, Silvia ; Murialdo, Giovanni ; Garibotto, Giacomo ; Vera, Lara ; Ameri, Pietro ; Repetto, Barbara ; Naseri, Mehrdad ; Bossert, Irene ; Verardi, Maria Teresa ; Massollo, Michela ; Marini, Cecilia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-14b87615c0bd7fe9efa2cce20408fa92e196acc1b91e13c5fe78a360536296f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Biological Availability</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - metabolism</topic><topic>Coronary Circulation</topic><topic>Electrocardiography - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperparathyroidism - metabolism</topic><topic>Imaging</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microcirculation</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - physiology</topic><topic>Myocardium - pathology</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Organophosphorus Compounds - pharmacology</topic><topic>Organotechnetium Compounds - pharmacology</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Perfusion</topic><topic>Pulmonary Artery - metabolism</topic><topic>Radiology</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Tomography, Emission-Computed, Single-Photon - methods</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Capitanio, Selene</creatorcontrib><creatorcontrib>Sambuceti, Gianmario</creatorcontrib><creatorcontrib>Giusti, Massimo</creatorcontrib><creatorcontrib>Morbelli, Silvia</creatorcontrib><creatorcontrib>Murialdo, Giovanni</creatorcontrib><creatorcontrib>Garibotto, Giacomo</creatorcontrib><creatorcontrib>Vera, Lara</creatorcontrib><creatorcontrib>Ameri, Pietro</creatorcontrib><creatorcontrib>Repetto, Barbara</creatorcontrib><creatorcontrib>Naseri, Mehrdad</creatorcontrib><creatorcontrib>Bossert, Irene</creatorcontrib><creatorcontrib>Verardi, Maria Teresa</creatorcontrib><creatorcontrib>Massollo, Michela</creatorcontrib><creatorcontrib>Marini, Cecilia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Capitanio, Selene</au><au>Sambuceti, Gianmario</au><au>Giusti, Massimo</au><au>Morbelli, Silvia</au><au>Murialdo, Giovanni</au><au>Garibotto, Giacomo</au><au>Vera, Lara</au><au>Ameri, Pietro</au><au>Repetto, Barbara</au><au>Naseri, Mehrdad</au><au>Bossert, Irene</au><au>Verardi, Maria Teresa</au><au>Massollo, Michela</au><au>Marini, Cecilia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1,25-Dihydroxy vitamin D and coronary microvascular function</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><stitle>Eur J Nucl Med Mol Imaging</stitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2013</date><risdate>2013</risdate><volume>40</volume><issue>2</issue><spage>280</spage><epage>289</epage><pages>280-289</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Purpose
The active form of vitamin D (1,25(OH)
2
D) contributes to blood flow regulation in skeletal muscle. The aim of the present study was to determine whether this hormone also modulates coronary physiology, and thus whether abnormalities in its bioavailability contribute to excess cardiovascular risk in patients with disorders of mineral metabolism.
Methods
As a clinical model of the wide variability in 1,25(OH)
2
D bioavailability, we studied 23 patients (62 ± 8 years) with suspected primary hyperparathyroidism referred for myocardial perfusion imaging because of atypical chest pain and at least one cardiovascular risk factor. Dipyridamole and baseline myocardial blood flow indexes were assessed on G-SPECT imaging of
99m
Tc-tetrofosmin, with normalization of the myocardial count rate to the corresponding first-transit counts in the pulmonary artery. Coronary flow reserve (CFR) was defined as the ratio between dipyridamole and baseline myocardial blood flow indexes. In all patients, parathyroid hormone, 25-hydroxy vitamin D (25(OH)D) and 1,25(OH)
2
D serum levels were determined.
Results
Primary hyperparathyroidism was eventually diagnosed in 15 of the 23 patients. The mean 25(OH)D concentration was relatively low (21 ± 10 ng/mL) while the concentrations of 1,25(OH)
2
D varied widely but within the normal range (mean 95 ± 61 pmol/L). No patient showed reversible perfusion defects on G-SPECT. CFR was not correlated with either the serum concentration of 25(OH)D nor that of parathyroid hormone, but was strictly correlated with the serum level of 1,25(OH)
2
D (
R
= 0.8,
p
< 0.01). Moreover, patients with a 1,25(OH)
2
D concentration below the median value (86 pmol/L) had markedly lower CFR than the other patients (1.48 ± 0.40 vs. 2.51 ± 0.63, respectively;
p
< 0.001).
Conclusion
Bioavailable 1,25(OH)
2
D modulates coronary microvascular function. This effect might contribute to the high cardiovascular risk of conditions characterized by chronic reduction in bioavailability of this hormone.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>23151909</pmid><doi>10.1007/s00259-012-2271-0</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1619-7070 |
| ispartof | European journal of nuclear medicine and molecular imaging, 2013, Vol.40 (2), p.280-289 |
| issn | 1619-7070 1619-7089 |
| language | eng |
| recordid | cdi_proquest_journals_1461756531 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Aged Biological Availability Cardiology Cardiovascular disease Cardiovascular Diseases - metabolism Coronary Circulation Electrocardiography - methods Female Humans Hyperparathyroidism - metabolism Imaging Male Medical imaging Medicine Medicine & Public Health Microcirculation Middle Aged Muscle, Skeletal - metabolism Muscle, Skeletal - physiology Myocardium - pathology Nuclear Medicine Oncology Organophosphorus Compounds - pharmacology Organotechnetium Compounds - pharmacology Original Article Orthopedics Perfusion Pulmonary Artery - metabolism Radiology Risk Risk Factors Tomography, Emission-Computed, Single-Photon - methods Vitamin D Vitamin D - analogs & derivatives Vitamin D - metabolism |
| title | 1,25-Dihydroxy vitamin D and coronary microvascular function |
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