PEG-mediated Facile Protocol for N-Boc Protection of Amines

We have reported an efficient and eco-friendly protocol for the protection of various structurally and electronically divergent aryl and aliphatic amines using (Boc)2O in the presence of PEG-400 at room temperature. The reaction gave excellent yields with low as well as high molecular weight PEGs.

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Veröffentlicht in:Chemistry letters 2010-11, Vol.39 (11), p.1127-1129
Hauptverfasser: Siddaiah, V, Basha, G. M, Rao, G. Padma, Prasad, U. Viplava, Rao, R. Suryachendra
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container_end_page 1129
container_issue 11
container_start_page 1127
container_title Chemistry letters
container_volume 39
creator Siddaiah, V
Basha, G. M
Rao, G. Padma
Prasad, U. Viplava
Rao, R. Suryachendra
description We have reported an efficient and eco-friendly protocol for the protection of various structurally and electronically divergent aryl and aliphatic amines using (Boc)2O in the presence of PEG-400 at room temperature. The reaction gave excellent yields with low as well as high molecular weight PEGs.
doi_str_mv 10.1246/cl.2010.1127
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title PEG-mediated Facile Protocol for N-Boc Protection of Amines
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