Synthesis of Oligosaccharides of Genistein and Quercetin as Potential Anti-inflammatory Agents

Synthesis of Oligosaccharides of Genistein and Quercetin as Potential Anti-inflammatory Agents

Genistein was glucosylated to its 7-O-β-D-glucoside by cultured cells of Ipomoea batatas, while cultured Marchantia polymorpha cells produced 4′-O-β-D-glucoside and 7-O-β-D-glucoside of genistein. On the other hand, quercetin was converted into its 3-O-β-D-glucoside by I. batatas, and M. polymorpha...

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Veröffentlicht in:Chemistry letters 2008-08, Vol.37 (8), p.876-877
Hauptverfasser: Shimoda, Kei, Kobayashi, Tatsunari, Akagi, Masaaki, Hamada, Hatsuyuki, Hamada, Hiroki
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container_end_page 877
container_issue 8
container_start_page 876
container_title Chemistry letters
container_volume 37
creator Shimoda, Kei
Kobayashi, Tatsunari
Akagi, Masaaki
Hamada, Hatsuyuki
Hamada, Hiroki
description Genistein was glucosylated to its 7-O-β-D-glucoside by cultured cells of Ipomoea batatas, while cultured Marchantia polymorpha cells produced 4′-O-β-D-glucoside and 7-O-β-D-glucoside of genistein. On the other hand, quercetin was converted into its 3-O-β-D-glucoside by I. batatas, and M. polymorpha gave 3-O-β-D-glucoside and 7-O-β-D-glucoside of quercetin. These four glucosides were further glycosylated to the corresponding β-maltosides and β-maltotriosides by cyclodextrin glucanotransferase. Genistein 7-O-β-maltooligosaccharides, quercetin 3-O-β-glucoside, and quercetin 7-O-β-maltooligosaccharides showed potent inhibitory effects on histamine release from rat peritoneal mast cells.
doi_str_mv 10.1246/cl.2008.876
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title Synthesis of Oligosaccharides of Genistein and Quercetin as Potential Anti-inflammatory Agents
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