Alkylation of [alpha]-Halo Diketones via Enol Phosphate Intermediate

Alkylation of [alpha]-Halo Diketones via Enol Phosphate Intermediate

β-Substituted α,β-unsaturated carbonyl compounds were obtained in moderate to high yields by a 1,4-addition of organocuprates to enol phosphate intermediates formed in situ from triethyl phosphite and 2-bromo-1,3-dicarbonyl compounds.

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Veröffentlicht in:Chemistry letters 2003-11, Vol.32 (11), p.994
Hauptverfasser: Yoshitaka Onishi, Jim, Takuwa, Tomofumi, Mukaiyama, Teruaki
Format: Artikel
Sprache:eng
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Zusammenfassung:β-Substituted α,β-unsaturated carbonyl compounds were obtained in moderate to high yields by a 1,4-addition of organocuprates to enol phosphate intermediates formed in situ from triethyl phosphite and 2-bromo-1,3-dicarbonyl compounds.
ISSN:0366-7022
1348-0715