Synthesis and Antinociceptive Activity of Orally Active Opioid Peptides

To improve the oral bioavailability of a dermorphin tetrapeptide analog, Nα-1-iminoethyl-Tyr-D-MetO-Phe-MeβAla-OH (III),1) which has a potent analgesic activity after oral administration, various derivatives were synthesized to increase lipophilicity by esterification of the C-terminal carboxyl grou...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical & pharmaceutical bulletin 2003-07, Vol.51 (7), p.759
Hauptverfasser: Ogawa, Tadashi, Araki, Mamoru, Miyamae, Tetsuhisa, Okayama, Toru, Hagiwara, Masaki, Sakurada, Shinobu, Morikawa, Tadanori
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!