Bioactive Constituents from Chinese Natural Medicines. XIV.New Glycosides of [beta]-Carboline-Type Alkaloid, Neolignan, and Phenylpropanoid from Stellaria dichotoma L. var. lanceolata and Their Antiallergic Activities

Bioactive Constituents from Chinese Natural Medicines. XIV.New Glycosides of [beta]-Carboline-Type Alkaloid, Neolignan, and Phenylpropanoid from Stellaria dichotoma L. var. lanceolata and Their Antiallergic Activities

A new β-carboline-type alkaloidal glycoside, glucodichotomine B, four new neolignan glycosides, dichotomosides A, B, C, and D, and a new phenylpropanoid glycoside, dichotomoside E, were isolated from a Chinese natural medicine, the roots of Stellaria dichotoma L. var. lanceolata. The structures of t...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 2004-10, Vol.52 (10), p.1194
Hauptverfasser: Morikawa, Toshio, Sun, Bohang, Matsuda, Hisashi, Jun Wu, Li, Harima, Shoichi, Yoshikawa, Masayuki
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creator Morikawa, Toshio
Sun, Bohang
Matsuda, Hisashi
Jun Wu, Li
Harima, Shoichi
Yoshikawa, Masayuki
description A new β-carboline-type alkaloidal glycoside, glucodichotomine B, four new neolignan glycosides, dichotomosides A, B, C, and D, and a new phenylpropanoid glycoside, dichotomoside E, were isolated from a Chinese natural medicine, the roots of Stellaria dichotoma L. var. lanceolata. The structures of the new glycosides were determined on the basis of chemical and physicochemical evidence. Among them, dichotomoside D inhibited the release of β-hexosaminidase (IC50=64 μM) as well as tumor necrosis factor-α and interleukin-4 (IC50=16, 34 μM) in RBL-2H3 cells. These findings suggest that dichotomoside D is more effective against the late-phase reactions in type I allergy than in the immediate phase.
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XIV.New Glycosides of [beta]-Carboline-Type Alkaloid, Neolignan, and Phenylpropanoid from Stellaria dichotoma L. var. lanceolata and Their Antiallergic Activities</title><source>J-STAGE (Japan Science &amp; Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Morikawa, Toshio ; Sun, Bohang ; Matsuda, Hisashi ; Jun Wu, Li ; Harima, Shoichi ; Yoshikawa, Masayuki</creator><creatorcontrib>Morikawa, Toshio ; Sun, Bohang ; Matsuda, Hisashi ; Jun Wu, Li ; Harima, Shoichi ; Yoshikawa, Masayuki</creatorcontrib><description>A new β-carboline-type alkaloidal glycoside, glucodichotomine B, four new neolignan glycosides, dichotomosides A, B, C, and D, and a new phenylpropanoid glycoside, dichotomoside E, were isolated from a Chinese natural medicine, the roots of Stellaria dichotoma L. var. lanceolata. The structures of the new glycosides were determined on the basis of chemical and physicochemical evidence. Among them, dichotomoside D inhibited the release of β-hexosaminidase (IC50=64 μM) as well as tumor necrosis factor-α and interleukin-4 (IC50=16, 34 μM) in RBL-2H3 cells. 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title Bioactive Constituents from Chinese Natural Medicines. XIV.New Glycosides of [beta]-Carboline-Type Alkaloid, Neolignan, and Phenylpropanoid from Stellaria dichotoma L. var. lanceolata and Their Antiallergic Activities
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