Phosphodiesterase 4 Isoenzyme Inhibitory Activity of 3-Phenylxanthines and 4-Phenyl[i]condensed-purines

Phosphodiesterase 4 Isoenzyme Inhibitory Activity of 3-Phenylxanthines and 4-Phenyl[i]condensed-purines

On the basis of our study on the structure-activity relationships of 1, 3, 7-alkylxanthines and condensed-purines on cAMP-phosphodiesterase 4 (PDE 4) isoenzyme inhibitor, we investigated the synthesis and the inhibitory activity of 3-phenylxanthine and 4-phenyl[i]condensed-purine derivatives. Xanthi...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 2001, Vol.49(2), pp.188-191
Hauptverfasser: SUZUKI, Hirokazu, SAWANISHI, Hiroyuki, YAMAMOTO, Kenji, YOKOGAWA, Koichi, MIYAMOTO, Ken-ichi
Format: Artikel
Sprache:eng
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3-phenylxanthine
4-phenyl[i]condensed-purine
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Medical sciences
Pharmacology. Drug treatments
phosphodiesterase 4 inhibitor
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container_end_page 191
container_issue 2
container_start_page 188
container_title Chemical & pharmaceutical bulletin
container_volume 49
creator SUZUKI, Hirokazu
SAWANISHI, Hiroyuki
YAMAMOTO, Kenji
YOKOGAWA, Koichi
MIYAMOTO, Ken-ichi
description On the basis of our study on the structure-activity relationships of 1, 3, 7-alkylxanthines and condensed-purines on cAMP-phosphodiesterase 4 (PDE 4) isoenzyme inhibitor, we investigated the synthesis and the inhibitory activity of 3-phenylxanthine and 4-phenyl[i]condensed-purine derivatives. Xanthines and condensed-purines with the phenyl group exhibited potent and selective PDE 4 inhibitory activity.
doi_str_mv 10.1248/cpb.49.188
format Article
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source J-STAGE Free; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry
subjects 3-phenylxanthine
4-phenyl[i]condensed-purine
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Medical sciences
Pharmacology. Drug treatments
phosphodiesterase 4 inhibitor
title Phosphodiesterase 4 Isoenzyme Inhibitory Activity of 3-Phenylxanthines and 4-Phenyl[i]condensed-purines
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