Drug Release Characteristics of Ternary Mica/Phosphatidylcholine/Drug Intercalation Compounds
The intercalation of layered inorganic materials, synthetic mica (TSM), with drugs and their drug release characteristics were investigated using intermediate intercalation compounds with phosphatidylcholine (H-PC). Oil-soluble indomethacin and water-soluble imipramine chloride were selected as mode...
Gespeichert in:
| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1998/11/15, Vol.46(11), pp.1663-1666 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1666 |
|---|---|
| container_issue | 11 |
| container_start_page | 1663 |
| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 46 |
| creator | KANZAKI, Yasushi SHIMOYAMA, Yuko TSUKAMOTO, Maki OKANO, Motoko SUZUKI, Noriko INOUE, Yoshihiro TANAKA, Tatsuo KOIZUMI, Ken-ichi WATANABE, Yoshiteru |
| description | The intercalation of layered inorganic materials, synthetic mica (TSM), with drugs and their drug release characteristics were investigated using intermediate intercalation compounds with phosphatidylcholine (H-PC). Oil-soluble indomethacin and water-soluble imipramine chloride were selected as model drugs. The drug intercalation compounds were prepared by two methods. The first one was the "solvent method" in which the intermediate intercalation compound of TSM with H-PC was prepared in advance using a chloroform solution of H-PC. The intermediate was then mixed with a drug and heated at 180°C to prepare the ternary TSM/H-PC/drug compound. The second one was the "heating method" in which the mixture of (TSM+H-PC+drug) was heated at 180°C to prepare TSM/H-PC/drug directly. The release rate was controlled using a disintegrator (L-HPC). In the case of a tablet sample, the release rate indomethacin was controllable from 60 min (10% L-HPC) to longer than 420 min (3% L-HPC) in the case of the solvent method. A similar result was obtained in the case of imipramine chloride. |
| doi_str_mv | 10.1248/cpb.46.1663 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1460317418</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3133352791</sourcerecordid><originalsourceid>FETCH-LOGICAL-c580t-40a4430944ea12c751fe8145e7135cffdd97cd7f0f8ac87d20fcc2402413a27d3</originalsourceid><addsrcrecordid>eNpFkE1PwzAMhiMEEmNw4g9Ughvqlq827RENBpOGQGgcUWTSZO3UNSVpD_v3pNvELvbBjx_ZL0K3BE8I5dlUtT8Tnk5ImrIzNCKMizihlJ2jEcY4jylL2SW68n6DMU2wYCP0_eT6dfSpaw1eR7MSHKhOu8p3lfKRNdFKuwbcLnqrFEw_SuvbErqq2NWqtHXV6OlesGjCkoI6jGwTzey2tX1T-Gt0YaD2-ubYx-hr_ryavcbL95fF7HEZqyTDXcwxcM5wzrkGQpVIiNEZ4YkWhCXKmKLIhSqEwSYDlYmCYqMU5ZhywoCKgo3R3cHbOvvba9_Jje3D3bWXhKeYEcFJFqiHA6Wc9d5pI1tXbcNzkmA55CdDfpKncsgv0PdHJ_jwmXHQqMqfVlJBMBMBmx-wje9grf_n4EKCtR6UJE-yvZYc6-A_ASFzqRv2B7pGiPs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1460317418</pqid></control><display><type>article</type><title>Drug Release Characteristics of Ternary Mica/Phosphatidylcholine/Drug Intercalation Compounds</title><source>J-STAGE Free</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Free Full-Text Journals in Chemistry</source><creator>KANZAKI, Yasushi ; SHIMOYAMA, Yuko ; TSUKAMOTO, Maki ; OKANO, Motoko ; SUZUKI, Noriko ; INOUE, Yoshihiro ; TANAKA, Tatsuo ; KOIZUMI, Ken-ichi ; WATANABE, Yoshiteru</creator><creatorcontrib>KANZAKI, Yasushi ; SHIMOYAMA, Yuko ; TSUKAMOTO, Maki ; OKANO, Motoko ; SUZUKI, Noriko ; INOUE, Yoshihiro ; TANAKA, Tatsuo ; KOIZUMI, Ken-ichi ; WATANABE, Yoshiteru</creatorcontrib><description>The intercalation of layered inorganic materials, synthetic mica (TSM), with drugs and their drug release characteristics were investigated using intermediate intercalation compounds with phosphatidylcholine (H-PC). Oil-soluble indomethacin and water-soluble imipramine chloride were selected as model drugs. The drug intercalation compounds were prepared by two methods. The first one was the "solvent method" in which the intermediate intercalation compound of TSM with H-PC was prepared in advance using a chloroform solution of H-PC. The intermediate was then mixed with a drug and heated at 180°C to prepare the ternary TSM/H-PC/drug compound. The second one was the "heating method" in which the mixture of (TSM+H-PC+drug) was heated at 180°C to prepare TSM/H-PC/drug directly. The release rate was controlled using a disintegrator (L-HPC). In the case of a tablet sample, the release rate indomethacin was controllable from 60 min (10% L-HPC) to longer than 420 min (3% L-HPC) in the case of the solvent method. A similar result was obtained in the case of imipramine chloride.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.46.1663</identifier><identifier>CODEN: CPBTAL</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Biological and medical sciences ; drug delivery system ; General pharmacology ; indomethacin, imipramine ; intercalation ; Medical sciences ; mica ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; phosphatidylcholine</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1998/11/15, Vol.46(11), pp.1663-1666</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1999 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1998</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c580t-40a4430944ea12c751fe8145e7135cffdd97cd7f0f8ac87d20fcc2402413a27d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1671037$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>KANZAKI, Yasushi</creatorcontrib><creatorcontrib>SHIMOYAMA, Yuko</creatorcontrib><creatorcontrib>TSUKAMOTO, Maki</creatorcontrib><creatorcontrib>OKANO, Motoko</creatorcontrib><creatorcontrib>SUZUKI, Noriko</creatorcontrib><creatorcontrib>INOUE, Yoshihiro</creatorcontrib><creatorcontrib>TANAKA, Tatsuo</creatorcontrib><creatorcontrib>KOIZUMI, Ken-ichi</creatorcontrib><creatorcontrib>WATANABE, Yoshiteru</creatorcontrib><title>Drug Release Characteristics of Ternary Mica/Phosphatidylcholine/Drug Intercalation Compounds</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>The intercalation of layered inorganic materials, synthetic mica (TSM), with drugs and their drug release characteristics were investigated using intermediate intercalation compounds with phosphatidylcholine (H-PC). Oil-soluble indomethacin and water-soluble imipramine chloride were selected as model drugs. The drug intercalation compounds were prepared by two methods. The first one was the "solvent method" in which the intermediate intercalation compound of TSM with H-PC was prepared in advance using a chloroform solution of H-PC. The intermediate was then mixed with a drug and heated at 180°C to prepare the ternary TSM/H-PC/drug compound. The second one was the "heating method" in which the mixture of (TSM+H-PC+drug) was heated at 180°C to prepare TSM/H-PC/drug directly. The release rate was controlled using a disintegrator (L-HPC). In the case of a tablet sample, the release rate indomethacin was controllable from 60 min (10% L-HPC) to longer than 420 min (3% L-HPC) in the case of the solvent method. A similar result was obtained in the case of imipramine chloride.</description><subject>Biological and medical sciences</subject><subject>drug delivery system</subject><subject>General pharmacology</subject><subject>indomethacin, imipramine</subject><subject>intercalation</subject><subject>Medical sciences</subject><subject>mica</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>phosphatidylcholine</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNpFkE1PwzAMhiMEEmNw4g9Ughvqlq827RENBpOGQGgcUWTSZO3UNSVpD_v3pNvELvbBjx_ZL0K3BE8I5dlUtT8Tnk5ImrIzNCKMizihlJ2jEcY4jylL2SW68n6DMU2wYCP0_eT6dfSpaw1eR7MSHKhOu8p3lfKRNdFKuwbcLnqrFEw_SuvbErqq2NWqtHXV6OlesGjCkoI6jGwTzey2tX1T-Gt0YaD2-ubYx-hr_ryavcbL95fF7HEZqyTDXcwxcM5wzrkGQpVIiNEZ4YkWhCXKmKLIhSqEwSYDlYmCYqMU5ZhywoCKgo3R3cHbOvvba9_Jje3D3bWXhKeYEcFJFqiHA6Wc9d5pI1tXbcNzkmA55CdDfpKncsgv0PdHJ_jwmXHQqMqfVlJBMBMBmx-wje9grf_n4EKCtR6UJE-yvZYc6-A_ASFzqRv2B7pGiPs</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>KANZAKI, Yasushi</creator><creator>SHIMOYAMA, Yuko</creator><creator>TSUKAMOTO, Maki</creator><creator>OKANO, Motoko</creator><creator>SUZUKI, Noriko</creator><creator>INOUE, Yoshihiro</creator><creator>TANAKA, Tatsuo</creator><creator>KOIZUMI, Ken-ichi</creator><creator>WATANABE, Yoshiteru</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>1998</creationdate><title>Drug Release Characteristics of Ternary Mica/Phosphatidylcholine/Drug Intercalation Compounds</title><author>KANZAKI, Yasushi ; SHIMOYAMA, Yuko ; TSUKAMOTO, Maki ; OKANO, Motoko ; SUZUKI, Noriko ; INOUE, Yoshihiro ; TANAKA, Tatsuo ; KOIZUMI, Ken-ichi ; WATANABE, Yoshiteru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c580t-40a4430944ea12c751fe8145e7135cffdd97cd7f0f8ac87d20fcc2402413a27d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Biological and medical sciences</topic><topic>drug delivery system</topic><topic>General pharmacology</topic><topic>indomethacin, imipramine</topic><topic>intercalation</topic><topic>Medical sciences</topic><topic>mica</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>phosphatidylcholine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KANZAKI, Yasushi</creatorcontrib><creatorcontrib>SHIMOYAMA, Yuko</creatorcontrib><creatorcontrib>TSUKAMOTO, Maki</creatorcontrib><creatorcontrib>OKANO, Motoko</creatorcontrib><creatorcontrib>SUZUKI, Noriko</creatorcontrib><creatorcontrib>INOUE, Yoshihiro</creatorcontrib><creatorcontrib>TANAKA, Tatsuo</creatorcontrib><creatorcontrib>KOIZUMI, Ken-ichi</creatorcontrib><creatorcontrib>WATANABE, Yoshiteru</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KANZAKI, Yasushi</au><au>SHIMOYAMA, Yuko</au><au>TSUKAMOTO, Maki</au><au>OKANO, Motoko</au><au>SUZUKI, Noriko</au><au>INOUE, Yoshihiro</au><au>TANAKA, Tatsuo</au><au>KOIZUMI, Ken-ichi</au><au>WATANABE, Yoshiteru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drug Release Characteristics of Ternary Mica/Phosphatidylcholine/Drug Intercalation Compounds</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1998</date><risdate>1998</risdate><volume>46</volume><issue>11</issue><spage>1663</spage><epage>1666</epage><pages>1663-1666</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>The intercalation of layered inorganic materials, synthetic mica (TSM), with drugs and their drug release characteristics were investigated using intermediate intercalation compounds with phosphatidylcholine (H-PC). Oil-soluble indomethacin and water-soluble imipramine chloride were selected as model drugs. The drug intercalation compounds were prepared by two methods. The first one was the "solvent method" in which the intermediate intercalation compound of TSM with H-PC was prepared in advance using a chloroform solution of H-PC. The intermediate was then mixed with a drug and heated at 180°C to prepare the ternary TSM/H-PC/drug compound. The second one was the "heating method" in which the mixture of (TSM+H-PC+drug) was heated at 180°C to prepare TSM/H-PC/drug directly. The release rate was controlled using a disintegrator (L-HPC). In the case of a tablet sample, the release rate indomethacin was controllable from 60 min (10% L-HPC) to longer than 420 min (3% L-HPC) in the case of the solvent method. A similar result was obtained in the case of imipramine chloride.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><doi>10.1248/cpb.46.1663</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-2363 |
| ispartof | Chemical and Pharmaceutical Bulletin, 1998/11/15, Vol.46(11), pp.1663-1666 |
| issn | 0009-2363 1347-5223 |
| language | eng |
| recordid | cdi_proquest_journals_1460317418 |
| source | J-STAGE Free; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Biological and medical sciences drug delivery system General pharmacology indomethacin, imipramine intercalation Medical sciences mica Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments phosphatidylcholine |
| title | Drug Release Characteristics of Ternary Mica/Phosphatidylcholine/Drug Intercalation Compounds |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T21%3A14%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Drug%20Release%20Characteristics%20of%20Ternary%20Mica/Phosphatidylcholine/Drug%20Intercalation%20Compounds&rft.jtitle=Chemical%20&%20pharmaceutical%20bulletin&rft.au=KANZAKI,%20Yasushi&rft.date=1998&rft.volume=46&rft.issue=11&rft.spage=1663&rft.epage=1666&rft.pages=1663-1666&rft.issn=0009-2363&rft.eissn=1347-5223&rft.coden=CPBTAL&rft_id=info:doi/10.1248/cpb.46.1663&rft_dat=%3Cproquest_cross%3E3133352791%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1460317418&rft_id=info:pmid/&rfr_iscdi=true |