Synthesis and Quantitative Structure-Activity Relationship of N-(3-Oxo-3, 4-dihydro-2H-benzo[1, 4]oxazine-5-carbonyl)guanidines as Na/H Exchange Inhibitors

N-(3-Oxo-3, 4-dihydro-2H-benzo[1, 4]oxazine-6-carbonyl)guanidines 4 were prepared and tested for Na/H exchange inhibitory activities in order to clarify the structure-activity relationship (SAR). Quantitative SAR (QSAR) analysis of 6-carbonylguanidines 4 indicated that the length of the 4-substituen...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chemical & pharmaceutical bulletin 1998/11/15, Vol.46(11), pp.1716-1723
Hauptverfasser:	YAMAMOTO, Takeshi, HORI, Manabu, WATANABE, Ikuo, TSUTSUI, Hisayoshi, HARADA, Kengo, IKEDA, Shoji, MARUO, Joji, MORITA, Tominori, OHTAKA, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	ischemia-reperfusion injury KB-R9032 Na/H exchange inhibitor quantitative structure-activity relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!