Cytoprotective Effects of 4, 6-Bis(1H-pyrazol-1-yl)pyrimidine and Related Compounds on HCl·Ethanol-Induced Gastric Lesions in Rats
Bis(1H-pyrazol-1-yl)- and bis(1H-imidazol-1-yl)pyrimidines were synthesized and evaluated for cytoprotective effects. Among them, 4, 6-bis(1H-pyrazol-1-yl)pyrimidine (3) showed a potent inhibitory effect on the HCl·ethanol-, ethanol-, and water immersion stress-induced gastric lesions in rats, and a...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1997/03/15, Vol.45(3), pp.549-551 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | IKEDA, Masazumi MARUYAMA, Kazumi NOBUHARA, Youichi YAMADA, Toshihiro OKABE, Susumu |
| description | Bis(1H-pyrazol-1-yl)- and bis(1H-imidazol-1-yl)pyrimidines were synthesized and evaluated for cytoprotective effects. Among them, 4, 6-bis(1H-pyrazol-1-yl)pyrimidine (3) showed a potent inhibitory effect on the HCl·ethanol-, ethanol-, and water immersion stress-induced gastric lesions in rats, and a very low acute toxicity. One of the major factors reponsible for the cytoprotective effects of 3 is the increase in the bicarbonate secretion. This compound appears to be a promising cytoprotective drug for the treatment of gastric mucosal ulcers. |
| doi_str_mv | 10.1248/cpb.45.549 |
| format | Article |
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This compound appears to be a promising cytoprotective drug for the treatment of gastric mucosal ulcers.</description><subject>4, 6-bis(1H-pyrazol-1-yl)pyrimidine</subject><subject>bicarbonate secretion</subject><subject>cytoprotective effect</subject><subject>dulcerozine</subject><subject>mepirizole</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNpFUE1LxDAQDaLgunrxFwS8KJg1n21z1LLuLiwIy95D2qZuSk1rkwr16o_y7i8zsIKXmTfMezO8B8A1wQtCefZQ9sWCi4Xg8gTMCOMpEpSyUzDDGEtEWcLOwYX3DcZU4JTNwFc-ha4fumDKYD8MXNZ1RB52NeT3MEFP1t-SNeqnQX92LSJoau_iYN9sZZ2B2lVwZ1odTAXz7q3vRldFsYPrvP35XoaDdlG1cdVYRsZK-zDYEm6Nt53z0Dq408FfgrNat95c_fU52D8v9_kabV9Wm_xxixqSkYBMIiSRmKU4qStiUk4lF1oKXUgsGS14RiueRZByTTPOamEYqZNCl6TWkrI5uDmejXbfR-ODarpxcPGjIjzBjGDCZWTlR1bjg341qo9e9TApPQRbtkbFhIkUmeJCsWOJYf9vD3pQxrFfST94rA</recordid><startdate>19970301</startdate><enddate>19970301</enddate><creator>IKEDA, Masazumi</creator><creator>MARUYAMA, Kazumi</creator><creator>NOBUHARA, Youichi</creator><creator>YAMADA, Toshihiro</creator><creator>OKABE, Susumu</creator><general>The Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>19970301</creationdate><title>Cytoprotective Effects of 4, 6-Bis(1H-pyrazol-1-yl)pyrimidine and Related Compounds on HCl·Ethanol-Induced Gastric Lesions in Rats</title><author>IKEDA, Masazumi ; MARUYAMA, Kazumi ; NOBUHARA, Youichi ; YAMADA, Toshihiro ; OKABE, Susumu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j181t-e6591903706fd1e742945a95ab90932b482d4832b74a2843f5e31f6bac1fa923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>4, 6-bis(1H-pyrazol-1-yl)pyrimidine</topic><topic>bicarbonate secretion</topic><topic>cytoprotective effect</topic><topic>dulcerozine</topic><topic>mepirizole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>IKEDA, Masazumi</creatorcontrib><creatorcontrib>MARUYAMA, Kazumi</creatorcontrib><creatorcontrib>NOBUHARA, Youichi</creatorcontrib><creatorcontrib>YAMADA, Toshihiro</creatorcontrib><creatorcontrib>OKABE, Susumu</creatorcontrib><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IKEDA, Masazumi</au><au>MARUYAMA, Kazumi</au><au>NOBUHARA, Youichi</au><au>YAMADA, Toshihiro</au><au>OKABE, Susumu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytoprotective Effects of 4, 6-Bis(1H-pyrazol-1-yl)pyrimidine and Related Compounds on HCl·Ethanol-Induced Gastric Lesions in Rats</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1997-03-01</date><risdate>1997</risdate><volume>45</volume><issue>3</issue><spage>549</spage><epage>551</epage><pages>549-551</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>Bis(1H-pyrazol-1-yl)- and bis(1H-imidazol-1-yl)pyrimidines were synthesized and evaluated for cytoprotective effects. Among them, 4, 6-bis(1H-pyrazol-1-yl)pyrimidine (3) showed a potent inhibitory effect on the HCl·ethanol-, ethanol-, and water immersion stress-induced gastric lesions in rats, and a very low acute toxicity. One of the major factors reponsible for the cytoprotective effects of 3 is the increase in the bicarbonate secretion. This compound appears to be a promising cytoprotective drug for the treatment of gastric mucosal ulcers.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><doi>10.1248/cpb.45.549</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | 4, 6-bis(1H-pyrazol-1-yl)pyrimidine bicarbonate secretion cytoprotective effect dulcerozine mepirizole |
| title | Cytoprotective Effects of 4, 6-Bis(1H-pyrazol-1-yl)pyrimidine and Related Compounds on HCl·Ethanol-Induced Gastric Lesions in Rats |
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