NOVEL FLUOROPROSTACYCLIN ANALOGS WITH MODIFIED CYCLOALKYLENYL CHAINS. HIGHLY POTENT AND ORALLY ACTIVE ANTI-ANGINAL AGENTS

Novel fluoroprostacyclin analogs (1a-f) have been synthesized and pharmacologically evaluated. Compounds 1a-c given intravenously or orally showed potent and long-lasting anti-anginal activities in an animal model.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 1995/02/15, Vol.43(2), pp.353-355
Hauptverfasser:	MATSUMURA, Yasushi, ASAI, Tomoyuki, SHIMADA, Toyomichi, NAKAYAMA, Toshiaki, URUSHIHARA, Masahiro, MORIZAWA, Yoshitomi, YASUDA, Aarata, YAMAMOTO, Taku, FUJITANI, Buichi, HOSOKI, Kanoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Angina Pectoris - drug therapy Animals anti-anginal activity Antianginal agents. Coronary vasodilator agents Biological and medical sciences Blood Pressure - drug effects Cardiovascular system Dose-Response Relationship, Drug Drug Evaluation Electrocardiography - drug effects Epoprostenol - administration & dosage Epoprostenol - analogs & derivatives Epoprostenol - pharmacology Epoprostenol - therapeutic use Fluorine - chemistry fluoroprostacyclin Guinea Pigs Heart - drug effects hypotensive effect iloprost Iloprost - administration & dosage Iloprost - pharmacology Injections, Intravenous Medical sciences Pharmacology. Drug treatments Platelet Aggregation - drug effects platelet aggregation inhibition Rats Stereoisomerism Structure-Activity Relationship Vasopressins - toxicity β-oxidation
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