Effects of 3, 3'-dihydroxy-[alpha], [beta]-diethylstilbene and 3, 3', 4, 5'-Tetrahydroxystilbene on Microtubule Assembly in Vitro, Aneuploidy Induction, and Cellular Microtubule and Actin Networks

Effects of 3, 3'-dihydroxy-[alpha], [beta]-diethylstilbene and 3, 3', 4, 5'-Tetrahydroxystilbene on Microtubule Assembly in Vitro, Aneuploidy Induction, and Cellular Microtubule and Actin Networks

We examined the inhibitory activities of 3, 3'-dihydroxy-α, β-diethylstilbene (DDS) and 3, 3', 4, 5'-tetrahydroxystilbene (THS) on microtubule assembly in vitro and their effects on chromosome number and cellular microtubule networks in Chinese hamster V79 cells. DDS showed half the i...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical & pharmaceutical bulletin 1992-08, Vol.40 (8), p.2115
Hauptverfasser: SAKAKIBARA, Yumiko, SAITO, Izumi, ODA, Taiko, TSUJIBO, Hiroshi, INAMORI, Yoshihiko, SATO, Yoshihiro
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 8
container_start_page 2115
container_title Chemical & pharmaceutical bulletin
container_volume 40
creator SAKAKIBARA, Yumiko
SAITO, Izumi
ODA, Taiko
TSUJIBO, Hiroshi
INAMORI, Yoshihiko
SATO, Yoshihiro
description We examined the inhibitory activities of 3, 3'-dihydroxy-α, β-diethylstilbene (DDS) and 3, 3', 4, 5'-tetrahydroxystilbene (THS) on microtubule assembly in vitro and their effects on chromosome number and cellular microtubule networks in Chinese hamster V79 cells. DDS showed half the inhibitory activity of diethylstilbestrol (DES) on microtubule assembly in vitro, while THS had none of the inhibitory activity. DDS induced tetraploid at 30 μM, whereas THS was found to be inactive. Furthermore, DDS disturbed cellular microtubule networks at 100 μM.We also examined the effects of DES, DDS and THS on cellular actin networks in mouse BALB 3T3 cells. DES induced a change of actin stress fiber distribution and THS had similar activity, while DDS showed no activity.
format Article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_1460265021</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3132994021</sourcerecordid><originalsourceid>FETCH-proquest_journals_14602650213</originalsourceid><addsrcrecordid>eNqNjLtOwzAYRi0EEuHyDr_E0MWWHDtJxRhVRTDQqWKpqspJ_iguxg6-CPJ-PBgFKiQ2pm8453wnJMtlMWelEPKUZJzzWyZkJc_JRQh7zkXJ5zIjH8u-xzYGcD1ICnLGOj1MnXfvE9soMw5qS2HTYFTbA8E4TCZEbRq0CMp2Pw2FgkI5Y2uMXh3rX8tZeNStdzE1ySDUIeBLYybQFp509I5CbTGNxuluggfbpTZqZ-n3-wKNSUb5Pw9foD5IFlYY35x_DlfkrFcm4PVxL8nN3XK9uGejd68JQ9ztXfL2gHZ5UXFRlVzk8n_WJ6M9aEM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1460265021</pqid></control><display><type>article</type><title>Effects of 3, 3'-dihydroxy-[alpha], [beta]-diethylstilbene and 3, 3', 4, 5'-Tetrahydroxystilbene on Microtubule Assembly in Vitro, Aneuploidy Induction, and Cellular Microtubule and Actin Networks</title><source>J-STAGE (Japan Science &amp; Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>SAKAKIBARA, Yumiko ; SAITO, Izumi ; ODA, Taiko ; TSUJIBO, Hiroshi ; INAMORI, Yoshihiko ; SATO, Yoshihiro</creator><creatorcontrib>SAKAKIBARA, Yumiko ; SAITO, Izumi ; ODA, Taiko ; TSUJIBO, Hiroshi ; INAMORI, Yoshihiko ; SATO, Yoshihiro</creatorcontrib><description>We examined the inhibitory activities of 3, 3'-dihydroxy-α, β-diethylstilbene (DDS) and 3, 3', 4, 5'-tetrahydroxystilbene (THS) on microtubule assembly in vitro and their effects on chromosome number and cellular microtubule networks in Chinese hamster V79 cells. DDS showed half the inhibitory activity of diethylstilbestrol (DES) on microtubule assembly in vitro, while THS had none of the inhibitory activity. DDS induced tetraploid at 30 μM, whereas THS was found to be inactive. Furthermore, DDS disturbed cellular microtubule networks at 100 μM.We also examined the effects of DES, DDS and THS on cellular actin networks in mouse BALB 3T3 cells. DES induced a change of actin stress fiber distribution and THS had similar activity, while DDS showed no activity.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><language>eng</language><publisher>Tokyo: Japan Science and Technology Agency</publisher><ispartof>Chemical &amp; pharmaceutical bulletin, 1992-08, Vol.40 (8), p.2115</ispartof><rights>Copyright Japan Science and Technology Agency 1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>SAKAKIBARA, Yumiko</creatorcontrib><creatorcontrib>SAITO, Izumi</creatorcontrib><creatorcontrib>ODA, Taiko</creatorcontrib><creatorcontrib>TSUJIBO, Hiroshi</creatorcontrib><creatorcontrib>INAMORI, Yoshihiko</creatorcontrib><creatorcontrib>SATO, Yoshihiro</creatorcontrib><title>Effects of 3, 3'-dihydroxy-[alpha], [beta]-diethylstilbene and 3, 3', 4, 5'-Tetrahydroxystilbene on Microtubule Assembly in Vitro, Aneuploidy Induction, and Cellular Microtubule and Actin Networks</title><title>Chemical &amp; pharmaceutical bulletin</title><description>We examined the inhibitory activities of 3, 3'-dihydroxy-α, β-diethylstilbene (DDS) and 3, 3', 4, 5'-tetrahydroxystilbene (THS) on microtubule assembly in vitro and their effects on chromosome number and cellular microtubule networks in Chinese hamster V79 cells. DDS showed half the inhibitory activity of diethylstilbestrol (DES) on microtubule assembly in vitro, while THS had none of the inhibitory activity. DDS induced tetraploid at 30 μM, whereas THS was found to be inactive. Furthermore, DDS disturbed cellular microtubule networks at 100 μM.We also examined the effects of DES, DDS and THS on cellular actin networks in mouse BALB 3T3 cells. DES induced a change of actin stress fiber distribution and THS had similar activity, while DDS showed no activity.</description><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNqNjLtOwzAYRi0EEuHyDr_E0MWWHDtJxRhVRTDQqWKpqspJ_iguxg6-CPJ-PBgFKiQ2pm8453wnJMtlMWelEPKUZJzzWyZkJc_JRQh7zkXJ5zIjH8u-xzYGcD1ICnLGOj1MnXfvE9soMw5qS2HTYFTbA8E4TCZEbRq0CMp2Pw2FgkI5Y2uMXh3rX8tZeNStdzE1ySDUIeBLYybQFp509I5CbTGNxuluggfbpTZqZ-n3-wKNSUb5Pw9foD5IFlYY35x_DlfkrFcm4PVxL8nN3XK9uGejd68JQ9ztXfL2gHZ5UXFRlVzk8n_WJ6M9aEM</recordid><startdate>19920801</startdate><enddate>19920801</enddate><creator>SAKAKIBARA, Yumiko</creator><creator>SAITO, Izumi</creator><creator>ODA, Taiko</creator><creator>TSUJIBO, Hiroshi</creator><creator>INAMORI, Yoshihiko</creator><creator>SATO, Yoshihiro</creator><general>Japan Science and Technology Agency</general><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>19920801</creationdate><title>Effects of 3, 3'-dihydroxy-[alpha], [beta]-diethylstilbene and 3, 3', 4, 5'-Tetrahydroxystilbene on Microtubule Assembly in Vitro, Aneuploidy Induction, and Cellular Microtubule and Actin Networks</title><author>SAKAKIBARA, Yumiko ; SAITO, Izumi ; ODA, Taiko ; TSUJIBO, Hiroshi ; INAMORI, Yoshihiko ; SATO, Yoshihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_14602650213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SAKAKIBARA, Yumiko</creatorcontrib><creatorcontrib>SAITO, Izumi</creatorcontrib><creatorcontrib>ODA, Taiko</creatorcontrib><creatorcontrib>TSUJIBO, Hiroshi</creatorcontrib><creatorcontrib>INAMORI, Yoshihiko</creatorcontrib><creatorcontrib>SATO, Yoshihiro</creatorcontrib><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Chemical &amp; pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SAKAKIBARA, Yumiko</au><au>SAITO, Izumi</au><au>ODA, Taiko</au><au>TSUJIBO, Hiroshi</au><au>INAMORI, Yoshihiko</au><au>SATO, Yoshihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of 3, 3'-dihydroxy-[alpha], [beta]-diethylstilbene and 3, 3', 4, 5'-Tetrahydroxystilbene on Microtubule Assembly in Vitro, Aneuploidy Induction, and Cellular Microtubule and Actin Networks</atitle><jtitle>Chemical &amp; pharmaceutical bulletin</jtitle><date>1992-08-01</date><risdate>1992</risdate><volume>40</volume><issue>8</issue><spage>2115</spage><pages>2115-</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>We examined the inhibitory activities of 3, 3'-dihydroxy-α, β-diethylstilbene (DDS) and 3, 3', 4, 5'-tetrahydroxystilbene (THS) on microtubule assembly in vitro and their effects on chromosome number and cellular microtubule networks in Chinese hamster V79 cells. DDS showed half the inhibitory activity of diethylstilbestrol (DES) on microtubule assembly in vitro, while THS had none of the inhibitory activity. DDS induced tetraploid at 30 μM, whereas THS was found to be inactive. Furthermore, DDS disturbed cellular microtubule networks at 100 μM.We also examined the effects of DES, DDS and THS on cellular actin networks in mouse BALB 3T3 cells. DES induced a change of actin stress fiber distribution and THS had similar activity, while DDS showed no activity.</abstract><cop>Tokyo</cop><pub>Japan Science and Technology Agency</pub></addata></record>
fulltext fulltext
identifier ISSN: 0009-2363
ispartof Chemical & pharmaceutical bulletin, 1992-08, Vol.40 (8), p.2115
issn 0009-2363
1347-5223
language eng
recordid cdi_proquest_journals_1460265021
source J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry
title Effects of 3, 3'-dihydroxy-[alpha], [beta]-diethylstilbene and 3, 3', 4, 5'-Tetrahydroxystilbene on Microtubule Assembly in Vitro, Aneuploidy Induction, and Cellular Microtubule and Actin Networks
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T14%3A57%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%203,%203'-dihydroxy-%5Balpha%5D,%20%5Bbeta%5D-diethylstilbene%20and%203,%203',%204,%205'-Tetrahydroxystilbene%20on%20Microtubule%20Assembly%20in%20Vitro,%20Aneuploidy%20Induction,%20and%20Cellular%20Microtubule%20and%20Actin%20Networks&rft.jtitle=Chemical%20&%20pharmaceutical%20bulletin&rft.au=SAKAKIBARA,%20Yumiko&rft.date=1992-08-01&rft.volume=40&rft.issue=8&rft.spage=2115&rft.pages=2115-&rft.issn=0009-2363&rft.eissn=1347-5223&rft_id=info:doi/&rft_dat=%3Cproquest%3E3132994021%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1460265021&rft_id=info:pmid/&rfr_iscdi=true