Chemical Modification of Fumagillin. III. Modification of the Spiro-epoxide

The spiro-epoxy group of fumagillol (2) was selectively modified and several analogues of AGM-1470 (3) with a (dialkyl)-β-hydroxyethylsulfonium moiety were prepared. These analogues were found to inhibit angiogenesis induced by basic fibroblast growth factor in the rat micropocket assay. They also i...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1995/04/15, Vol.43(4), pp.588-593
Hauptverfasser:	MARUI, Shogo, YAMAMOTO, Toshihiro, SUDO, Katsuichi, AKIMOTO, Hiroshi, KISHIMOTO, Shoji
Format:	Artikel
Sprache:	eng
Schlagworte:	AGM-1470 anti-angiogenic activity Antineoplastic agents antitumor activity Biological and medical sciences fumagillin General aspects Medical sciences Pharmacology. Drug treatments sulfonium analogue
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