Chemical Modification of Fumagillin. III. Modification of the Spiro-epoxide

The spiro-epoxy group of fumagillol (2) was selectively modified and several analogues of AGM-1470 (3) with a (dialkyl)-β-hydroxyethylsulfonium moiety were prepared. These analogues were found to inhibit angiogenesis induced by basic fibroblast growth factor in the rat micropocket assay. They also i...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1995/04/15, Vol.43(4), pp.588-593
Hauptverfasser:	MARUI, Shogo, YAMAMOTO, Toshihiro, SUDO, Katsuichi, AKIMOTO, Hiroshi, KISHIMOTO, Shoji
Format:	Artikel
Sprache:	eng
Schlagworte:	AGM-1470 anti-angiogenic activity Antineoplastic agents antitumor activity Biological and medical sciences fumagillin General aspects Medical sciences Pharmacology. Drug treatments sulfonium analogue
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creator	MARUI, Shogo YAMAMOTO, Toshihiro SUDO, Katsuichi AKIMOTO, Hiroshi KISHIMOTO, Shoji
description	The spiro-epoxy group of fumagillol (2) was selectively modified and several analogues of AGM-1470 (3) with a (dialkyl)-β-hydroxyethylsulfonium moiety were prepared. These analogues were found to inhibit angiogenesis induced by basic fibroblast growth factor in the rat micropocket assay. They also inhibited the growth of M5076 cells in vivo, but did not affect the body weight change of the tested mice during the assay.
doi_str_mv	10.1248/cpb.43.588
format	Article
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subjects	AGM-1470 anti-angiogenic activity Antineoplastic agents antitumor activity Biological and medical sciences fumagillin General aspects Medical sciences Pharmacology. Drug treatments sulfonium analogue
title	Chemical Modification of Fumagillin. III. Modification of the Spiro-epoxide
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