N-COUMARINYL-L-PROLINE, A NOVEL CHIRAL DERIVATIZING AGENT FOR 1H NMR DETERMINATION OF ENANTIOMERIC PURITIES OF ALCOHOLS AND AMINES

N-(Coumarin-4-yl)-L-proline[CPRO-1], readily prepared from commercially available Cbz-L-proline and 4-hydroxycoumarin, was proved to be an efficient and useful chiral derivatizing agent by 1H NMR inspection of the resulting diastereomeric esters and amides.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 1995/02/15, Vol.43(2), pp.344-346
Hauptverfasser:	NAGASAWA, Kazuo, YAMASHITA, Asami, KATOH, Satoru, ITO, Keiichi, WADA, Kohji
Format:	Artikel
Sprache:	eng
Schlagworte:	1H NMR Chemistry chiral alcohol chiral amine chiral derivatizing agent enantiomeric purity Exact sciences and technology N-coumarinyl-L-proline Organic chemistry
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Beschreibung
Zusammenfassung:	N-(Coumarin-4-yl)-L-proline[CPRO-1], readily prepared from commercially available Cbz-L-proline and 4-hydroxycoumarin, was proved to be an efficient and useful chiral derivatizing agent by 1H NMR inspection of the resulting diastereomeric esters and amides.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.43.344