Total Synthesis of (±)-, (-)-, and (+)-Oudemansin X

Three kinds of oudemansin X, (-)-1, (+)-1 and (±)-1, were totally synthesized. The key point in the present chiral synthesis was the enantioselective acetylation of the racemic alcohols, (±)-5 and (±)-8, using lipase in an organic solvent. The synthetic (-)-1 was found to exhibit strong antifungal a...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1995/07/15, Vol.43(7), pp.1111-1118
Hauptverfasser:	UMEZAWA, Isao, NOZAWA, Masako, NAGUMO, Shinji, AKITA, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	antifungal activity Chemistry chiral synthesis enantioselective acetylation Exact sciences and technology lipase Noncondensed benzenic compounds Organic chemistry oudemansin X Preparations and properties total synthesis
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