neuropeptide speeds circadian entrainment by reducing intercellular synchrony

Shift work or transmeridian travel can desynchronize the body's circadian rhythms from local light–dark cycles. The mammalian suprachiasmatic nucleus (SCN) generates and entrains daily rhythms in physiology and behavior. Paradoxically, we found that vasoactive intestinal polypeptide (VIP), a ne...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-11, Vol.110 (46), p.E4355-E4361
Hauptverfasser:	An, Sungwon, Harang, Rich, Meeker, Kirsten, Granados-Fuentes, Daniel, Tsai, Connie A, Mazuski, Cristina, Kim, Jihee, Doyle, 3rd, Francis J, Petzold, Linda R, Herzog, Erik D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Clocks - drug effects Biological Clocks - physiology Biological Sciences Circadian rhythm Circadian Rhythm - drug effects Circadian Rhythm - physiology dose response Dose-Response Relationship, Drug Luminescent Measurements Male messenger RNA Mice Models, Biological Molecules Motor Activity - physiology neurons Period Circadian Proteins - metabolism Photoperiod PNAS Plus Polypeptides Shift work Signal Transduction - physiology Stochastic models Suprachiasmatic Nucleus - physiology Temperature travel vasoactive intestinal peptide Vasoactive Intestinal Peptide - metabolism Vasoactive Intestinal Peptide - pharmacology work schedules
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