Relative Inhibitory Activity of Berberine-Type Alkaloids against 12-[omicron]-Tetradecanoylphorbol-13-acetate-Induced Inflammation in Mice

Relative Inhibitory Activity of Berberine-Type Alkaloids against 12-[omicron]-Tetradecanoylphorbol-13-acetate-Induced Inflammation in Mice

Forty eight derivatives of berberine-type alkaloids were examined for their inhibition activity against the induction of edema on mouse ear by application of 12-O-tetradecanoylphorbol-13-acetate (TPA). Berberine had an inhibitory effect against TPA-induced ear edema at a grade corresponding to those...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1991-06, Vol.39 (6), p.1462
Hauptverfasser: YASUKAWA, Ken, TAKIDO, Michio, IKEKAWA, Tetsuro, SHIMADA, Fumitake, TAKEUCHI, Mieko, NAKAGAWA, Shigeki
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container_issue 6
container_start_page 1462
container_title Chemical & pharmaceutical bulletin
container_volume 39
creator YASUKAWA, Ken
TAKIDO, Michio
IKEKAWA, Tetsuro
SHIMADA, Fumitake
TAKEUCHI, Mieko
NAKAGAWA, Shigeki
description Forty eight derivatives of berberine-type alkaloids were examined for their inhibition activity against the induction of edema on mouse ear by application of 12-O-tetradecanoylphorbol-13-acetate (TPA). Berberine had an inhibitory effect against TPA-induced ear edema at a grade corresponding to those of quercetin, caffeine and cepharanthine.berberine derivatives had stronger inhibitory activity than palmatine derivatives. 9-N, N-Diphenylcarbamoyl derivatives of both 9-demethylberberine and 9-demethylpalmatine had rather strong activity. These inhibitory activities are about ten times the activity of the respective mother compounds. Furthermore, 9-N-monophenylcarbamoyl derivatives and N, N-diphenylcarbamoyl chloride are found to have no effect
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title Relative Inhibitory Activity of Berberine-Type Alkaloids against 12-[omicron]-Tetradecanoylphorbol-13-acetate-Induced Inflammation in Mice
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