Addition of 4-Ethoxyimidazoles to Dimethyl Acetylenedicarboxylate and Transformation of the Adducts to Pyrimidin-5-yl Acetates

Four new 4-ethoxy-2-substituted imidazoles (1) were synthesized and high reactivity toward electrophiles was observed at the 5-position rather than the N atoms. For example, 1 reacted with dimethyl acetylenedicarboxylate to afford dimethyl (4-ethoxyimidazol-5-yl)fumarates (6) and-maleates (5). When...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1988/05/25, Vol.36(5), pp.1669-1675
Hauptverfasser:	FURUYA, SYUICHI, OMURA, KIYOSHI, FURUKAWA, YOSHIYASU
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry dimethyl acetylenedicarboxylate Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Organic chemistry Preparations and properties
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