Chemical Modification of Glycyrrhetinic Acid in Relation to the Biological Activities

18β-Olean-12-ene-3β, 30-diol (deoxoglycyrrhetol) (4a) was prepared with a view to eliminating pseudoaldosteronism, a side-effect of glycyrrhetinic acid (1b), which is the sapogenin of Licorice saponin, glycyrrhizin (1a), while maintaining or enhancing the therapeutic activities. On reduction of the...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1987/05/25, Vol.35(5), pp.1910-1918
Hauptverfasser:	SHIBATA, SHOJI, TAKAHASHI, KUNIO, YANO, SHINGO, HARADA, MASATOSHI, SAITO, HIROSHI, TAMURA, YASUSHI, KUMAGAI, AKIRA, HIRABAYASHI, KAZUHIRO, YAMAMOTO, MIDORI, NAGATA, NOBUYUKI
Format:	Artikel
Sprache:	eng
Schlagworte:	13 -diene-3β 18β-olean-11 18β-olean-12-ene-3β, 30-diol 18β-olean-9 , 12-diene-3β, 30-diol Alicyclic compounds, terpenoids, prostaglandins, steroids Animals Anti-Inflammatory Agents - chemical synthesis Chemical Phenomena Chemistry deoxoglycyrrhetol Exact sciences and technology glycyrrhetinic acid Glycyrrhetinic Acid - analogs & derivatives Glycyrrhetinic Acid - chemical synthesis Glycyrrhetinic Acid - pharmacology glycyrrhizin Hypersensitivity - drug therapy Organic chemistry Preparations and properties Stomach Ulcer - chemically induced Terpenoids
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