Synthesis and Structure of Prolinal-Containing Peptides, and Their Use as Specific Inhibitors of Proly Endopeptidases

Peptide aldehydes are potent inhibitors of serine and cysteine proteases. In the present work, N-benzyloxycarbonyl (Z) dipeptides containing prolinal at the carboxyl terminus were syntheized as inhibitors of prolyl endopeptidases. Since no aldehyde proton was detected by proton nuclear magnetic reso...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1986/07/25, Vol.34(7), pp.2931-2936
Hauptverfasser:	NISHIKATA, MAKOTO, YOKOSAWA, HIDEYOSHI, ISHII, SHIN-ICHI
Format:	Artikel
Sprache:	eng
Schlagworte:	protease inhibitor
Online-Zugang:	Volltext
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