Chemical Modification of Ansamitocins. I. Synthesis and Properties of 4, 5-Deoxymaytansinoids

4, 5-Deoxymaytansinoids, e.g., 4, 5-deoxyansamitocin P-3 (VI) and 4, 5-deoxymaytansine (VII), were synthesized a) by conversion of maytansinol into 4, 5-deoxymaytansinol (V), followed by acylation using active esters of appropriate carboxylic acids, and b) by direct deoxygenation of the parent mayta...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1984/06/25, Vol.32(6), pp.2194-2199
Hauptverfasser:	KAWAI, AKIYOSHI, AKIMOTO, HIROSHI, HASHIMOTO, NAOTO, NOMURA, HIROAKI
Format:	Artikel
Sprache:	eng
Schlagworte:	antitumor activity Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Organic chemistry Preparations and properties
Online-Zugang:	Volltext
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