Further Studies on the Structure of Polysaccharides from the Bark of Melia azadirachta

Water-soluble polysaccharides, designated as GIIa and GIIIa, were isolated together with GIa and GIb from the bark of Melia azadirachta (Meliaceae), and their anti-inflammatory effect on carrageenan-induced edema was tested. GIIa and GIIIa each gave a single peak on high-performance liquid chromatog...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1984/04/25, Vol.32(4), pp.1385-1391
Hauptverfasser:	FUJIWARA, TADAMI, SUGISHITA, ETSUKO, TAKEDA, TADAHIRO, OGIHARA, YUKIO, SHIMIZU, MASAKI, NOMURA, TAKEO, TOMITA, YUTAKA
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Sprache:	eng
Schlagworte:	Biological and medical sciences C-NMR General pharmacology Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments
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container_title	Chemical & pharmaceutical bulletin
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creator	FUJIWARA, TADAMI SUGISHITA, ETSUKO TAKEDA, TADAHIRO OGIHARA, YUKIO SHIMIZU, MASAKI NOMURA, TAKEO TOMITA, YUTAKA
description	Water-soluble polysaccharides, designated as GIIa and GIIIa, were isolated together with GIa and GIb from the bark of Melia azadirachta (Meliaceae), and their anti-inflammatory effect on carrageenan-induced edema was tested. GIIa and GIIIa each gave a single peak on high-performance liquid chromatography and gel filtration. Methylation, periodate oxidation and carbon-13 nuclear magnetic resonance spectroscopic studies suggested that GIIa is composed of the following repeating unit : α-D-G1c1→4α-D-G1c1→3α-D-G1c1→3α-D-G1c6←1α-L-ArafGIIIa is [numbrical formula] a branched arabinofucoglucan containing a main chain of 1→4-linked α-D-glucopyranosyl units substituted in the 6 position with side chains of α-L-arabinofuranose and β-L-fucopyranose.
doi_str_mv	10.1248/cpb.32.1385
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Pharm. Bull.</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>32</volume><issue>4</issue><spage>1385</spage><epage>1391</epage><pages>1385-1391</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>Water-soluble polysaccharides, designated as GIIa and GIIIa, were isolated together with GIa and GIb from the bark of Melia azadirachta (Meliaceae), and their anti-inflammatory effect on carrageenan-induced edema was tested. GIIa and GIIIa each gave a single peak on high-performance liquid chromatography and gel filtration. 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title	Further Studies on the Structure of Polysaccharides from the Bark of Melia azadirachta
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