Synthesis of Des-Pro2-Bradykinin and Its Behavior in Chromatography

Synthesis of Des-Pro2-Bradykinin and Its Behavior in Chromatography

Des-Pro2-Bradykinin was synthesized by the classical solution method as a reference compound for a possible contaminant in synthetic bradykinins, and its behavior in various chromatographic analyses was examined. It showed almost the same Rf values as bradykinin under several different conditions in...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1981/12/25, Vol.29(12), pp.3734-3737
Hauptverfasser: NARUSE, MASAO, YOSHIZAWA, KUMIKO, KIMURA, TERUTOSHI, SAKAKIBARA, SHUMPEI
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hypotension
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container_issue 12
container_start_page 3734
container_title Chemical & pharmaceutical bulletin
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creator NARUSE, MASAO
YOSHIZAWA, KUMIKO
KIMURA, TERUTOSHI
SAKAKIBARA, SHUMPEI
description Des-Pro2-Bradykinin was synthesized by the classical solution method as a reference compound for a possible contaminant in synthetic bradykinins, and its behavior in various chromatographic analyses was examined. It showed almost the same Rf values as bradykinin under several different conditions in cellulose thin layer chromatography and in paper electrophoresis, but was clearly separable from bradykinin by reversed phase high performance liquid chromatography under specific conditions. Since des-Pro2-bradykinin was found to have a potent bradykinin-potentiating activity, contamination by this material should be carefully avoided in bradykinin synthesis.
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subjects hypotension
title Synthesis of Des-Pro2-Bradykinin and Its Behavior in Chromatography
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