Syntheses and Reactions of Some 2, 5-Disubstituted Pyrazine Monoxides

Syntheses and Reactions of Some 2, 5-Disubstituted Pyrazine Monoxides

The reactions of 2, 5-dimethylpyrazine 1-oxide (XI), 2, 5-diethylpyrazine 1-oxide (XIII), 2-methyl-5-phenylpyrazine 1-oxide (XV), and 2-methyl-5-phenylpyrazine 4-oxide (XVI) with phosphoryl chloride or acetic anhydride were studied. 2, 5-Dichloro-3, 6-dimethylpyrazine (III) and 2, 5-dichloro-3, 6-di...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1979/09/25, Vol.27(9), pp.2027-2041
Hauptverfasser: OHTA, AKIHIRO, AKITA, YASUO, HARA, MIYOKO
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α-aminobutyric anhydride
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container_end_page 2041
container_issue 9
container_start_page 2027
container_title Chemical & pharmaceutical bulletin
container_volume 27
creator OHTA, AKIHIRO
AKITA, YASUO
HARA, MIYOKO
description The reactions of 2, 5-dimethylpyrazine 1-oxide (XI), 2, 5-diethylpyrazine 1-oxide (XIII), 2-methyl-5-phenylpyrazine 1-oxide (XV), and 2-methyl-5-phenylpyrazine 4-oxide (XVI) with phosphoryl chloride or acetic anhydride were studied. 2, 5-Dichloro-3, 6-dimethylpyrazine (III) and 2, 5-dichloro-3, 6-diethylpyrazine (VII) were converted to the diketopiperazines, alanine anhydride (I) and α-aminobutyric anhydride (V), respectively, which were shown to exist in a cis configuration by examination of their PMR spectra.
doi_str_mv 10.1248/cpb.27.2027
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title Syntheses and Reactions of Some 2, 5-Disubstituted Pyrazine Monoxides
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