Triazolo [4, 5-d] pyrimidines. IV. The Grignard Reaction of 3-Substituted 3H-1, 2, 3-Triazolo [4, 5-d] pyrimidines

Grignard reactions of 3-methyl- (1m) and 3-phenyl-3H-1, 2, 3-triazolo [4, 5-d] pyrimidine (1p) resulted in the formation of 7-alkyl-6, 7-dihydro-3-methyl- (2m) and 7-alkyl-6, 7-dihydro-3-phenyl-3H-1, 2, 3-triazolo [4, 5-d] pyrimidines (2p) in moderate yields. These dihydro compounds 2m and 2p were converted into 7-alkyl-3-methyl- (3m) and 7-alkyl-3-phenyl-3H-1, 2, 3-triazolo [4, 5-d] pyrimidines (3p), respectively, by oxidation with potassium ferricyanide.