Effect of Biotin on Biochemical Changes following Isoproterenol-induced Myocardial Infarction in Rats

Effect of biotin on biochemical changes following isoproterenol-induced myocardial infarction in rats was investigated. Biotin inhibited an increase of myocardial water content, an elevation of plasma lactate dehydrogenase activity and a decrease of myocardial adenosine triphosphate (ATP) level in isoproterenol-treated rats. Prednisolone enhanced the inhibitory effects of biotin on myocardial water content and plasma lactate dehydrogenase activity, but did not influence on myocardial ATP level. A possible mechanism of the inhibition by biotin is discussed.