Synthesis of 2-Substituted-6-amino-4, 5-dihydropyrimidine

Synthesis of 2-Substituted-6-amino-4, 5-dihydropyrimidine

The convenient synthesis of 2-substituted-6-amino-4, 5-dihydropyrimidine from the reaction of imidic ester with 3-aminopropionitrile was reported. Next, 2-phenyl- (V) and 2-(2-acylaminoethyl)-6-amino-4, 5-dihydropyrimidines were investigated to clarify their predominant form in the possible from the...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1969/11/25, Vol.17(11), pp.2273-2278
Hauptverfasser: OKAMOTO, YOSHIHISA, TSUJI, TADAKAZU, UEDA, TAKEO
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container_issue 11
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container_title Chemical & pharmaceutical bulletin
container_volume 17
creator OKAMOTO, YOSHIHISA
TSUJI, TADAKAZU
UEDA, TAKEO
description The convenient synthesis of 2-substituted-6-amino-4, 5-dihydropyrimidine from the reaction of imidic ester with 3-aminopropionitrile was reported. Next, 2-phenyl- (V) and 2-(2-acylaminoethyl)-6-amino-4, 5-dihydropyrimidines were investigated to clarify their predominant form in the possible from the aspects of infrared spectra. Thus, it was found that V exists as the imino-form and 2-(2-acylaminoethyl)-6-amino-4, 5-dihydropyrimidines as the amino-form in the solid state. Further, it was described the synthesis of 3-acylaminopropionamidine possessing the heterocyclic ring for the purpose of potenciating the activity of benzamidopropionamidine which was studied previously.
doi_str_mv 10.1248/cpb.17.2273
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title Synthesis of 2-Substituted-6-amino-4, 5-dihydropyrimidine
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