Studies on Food Additives. VI. Metabolism of 2, 6-Di-tert-butyl-p-cresol (BHT) in a Rabbit. (1). Determination and Paper Chromatography of a Metabolite
Metabolism of the antioxidant, 2, 6-di-tert-butyl-p-cresol (BHT), was studied in a rabbit. After administration of 0.5g./kg. of BHT by mouth, 37.5% of it was excreted as glucuronides, 16.7% as ethereal sulfates, and 6.8% as free phenols. α-Hydroxy-2, 6-di-tert-butyl-p-cresol, 3, 5-di-tert-butyl-4-hy...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1962/02/25, Vol.10(2), pp.101-105 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | Akagi, Masuo Aoki, Isamu |
| description | Metabolism of the antioxidant, 2, 6-di-tert-butyl-p-cresol (BHT), was studied in a rabbit. After administration of 0.5g./kg. of BHT by mouth, 37.5% of it was excreted as glucuronides, 16.7% as ethereal sulfates, and 6.8% as free phenols. α-Hydroxy-2, 6-di-tert-butyl-p-cresol, 3, 5-di-tert-butyl-4-hydroxybenzoic acid and 4, 4'-ethylenebis (2, 6-di-tert-butylphenol) were identified by paper chromatography from the rabbit urine 24 hours after the administration of 0.5g./kg. of BHT. Unchanged BHT was isolated from the feces, but not from the urine. |
| doi_str_mv | 10.1248/cpb.10.101 |
| format | Article |
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VI. Metabolism of 2, 6-Di-tert-butyl-p-cresol (BHT) in a Rabbit. (1). Determination and Paper Chromatography of a Metabolite</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>Metabolism of the antioxidant, 2, 6-di-tert-butyl-p-cresol (BHT), was studied in a rabbit. After administration of 0.5g./kg. of BHT by mouth, 37.5% of it was excreted as glucuronides, 16.7% as ethereal sulfates, and 6.8% as free phenols. α-Hydroxy-2, 6-di-tert-butyl-p-cresol, 3, 5-di-tert-butyl-4-hydroxybenzoic acid and 4, 4'-ethylenebis (2, 6-di-tert-butylphenol) were identified by paper chromatography from the rabbit urine 24 hours after the administration of 0.5g./kg. of BHT. 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VI. Metabolism of 2, 6-Di-tert-butyl-p-cresol (BHT) in a Rabbit. (1). Determination and Paper Chromatography of a Metabolite</title><author>Akagi, Masuo ; Aoki, Isamu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3671-53f7ff72e8849324099efd2deda9fee9f510120ba6c9035a37a7a8941d2433aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1962</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akagi, Masuo</creatorcontrib><creatorcontrib>Aoki, Isamu</creatorcontrib><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akagi, Masuo</au><au>Aoki, Isamu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies on Food Additives. 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| title | Studies on Food Additives. VI. Metabolism of 2, 6-Di-tert-butyl-p-cresol (BHT) in a Rabbit. (1). Determination and Paper Chromatography of a Metabolite |
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