A New Synthetic Method for the Preparation of [alpha],[beta]-Didehydroamino Acid Derivatives by Means of a Wittig-Type Reaction. Syntheses of (2S, 4S)- and (2R, 4R)-4-Hydroxyprolines

Ethyl N-Boc- and N-Z-α-tosylglycinates were reacted with a variety of aldehydes in the presence of tributylphosphine and a base to afford the corresponding α,β-didehydroamino acid derivatives with high (Z)-selectivity in good yields. Moreover, ethyl (4S)- and (4R)-2-(N-Boc-amino)-4,5-isopropylidened...

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Veröffentlicht in:	Bulletin of the Chemical Society of Japan 2002-11, Vol.75 (11), p.2517
Hauptverfasser:	Kimura, Rumi, Nagano, Tanemasa, Kinoshita, Hideki
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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