A Chiral Bimetallic Lewis Acid as a Reaction Template. Asymmetric Reduction of Unsymmetric Ketones with LiBH4

A new series of chiral bimetallic Lewis acids, 5,5′-bis[(R)-2-aryl-1,3,2-dioxaborolan-4-one], have been prepared from L-(+)-tartaric acid and arylboronic acids. In the presence of these Lewis acids, unsymmetric ketones were reduced quantitatively by LiBH4, in moderate to good ee’s (up to 99% ee). Th...

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Veröffentlicht in:	Bulletin of the Chemical Society of Japan 1999-05, Vol.72 (5), p.1109-1113
Hauptverfasser:	Nozaki, Kyoko, Kobori, Kayo, Uemura, Toshitsugi, Tsutsumi, Takaharu, Takaya, Hidemasa, Hiyama, Tamejiro
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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