Cataractogenesis and surgical outcome in patients with uveitis

Purpose To compare the risk of cataract development, the surgical management and the prevalence of complications in 2 groups of patients with uveitis treated in 2000 and 2010. Methods Retrospective study of patients with uveitis referred to an academic centre for the diagnosis and treatment of uveit...

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Veröffentlicht in:Acta ophthalmologica (Oxford, England) England), 2013-08, Vol.91 (s252), p.0-0
Hauptverfasser: REMOND, A, LE HOANG, P, BODAGHI, B
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description Purpose To compare the risk of cataract development, the surgical management and the prevalence of complications in 2 groups of patients with uveitis treated in 2000 and 2010. Methods Retrospective study of patients with uveitis referred to an academic centre for the diagnosis and treatment of uveitis. An extensive work‐up based on clinical presentation was performed when necessary. Corticosteroids were the mainstay of therapy in 2000 but new immunosuppressive molecules and biologics were used in 2010. Two groups were analyzed based on the year of cataract surgery (group A:2000 and group B:2010). Demographic factors, delay between onset of uveitis and cataract surgery, improvement of visual acuity and major complications were studied. Phacoemulsification and intraocular lens implantation were performed in all cases respecting a 3‐month quiescence of uveitis and an efficient perioperative anti‐inflammatory regimen. Results The study included 125 eyes of 107 patients. 59 eyes (48 patients: F/M: 1.29) were operated in 2000 (group A) and 66 (59 patients: F/M: 1.5) in 2010 (group B). An associated condition was determined in 81 cases (75.5 %): mainly herpetic uveitis (9), sarcoidosis (7), tuberculosis (10), birdshot chorioretinopathy (7), Behcet's disease (8), spondyloarthropathy (10), Vogt‐Koyanagi‐Harada disease (5), Fuchs heterochromic iridocyclitis (8). Delay between onset of uveitis and surgery was 58.86 months in group A and 111.68 months in group B (p
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Methods Retrospective study of patients with uveitis referred to an academic centre for the diagnosis and treatment of uveitis. An extensive work‐up based on clinical presentation was performed when necessary. Corticosteroids were the mainstay of therapy in 2000 but new immunosuppressive molecules and biologics were used in 2010. Two groups were analyzed based on the year of cataract surgery (group A:2000 and group B:2010). Demographic factors, delay between onset of uveitis and cataract surgery, improvement of visual acuity and major complications were studied. Phacoemulsification and intraocular lens implantation were performed in all cases respecting a 3‐month quiescence of uveitis and an efficient perioperative anti‐inflammatory regimen. Results The study included 125 eyes of 107 patients. 59 eyes (48 patients: F/M: 1.29) were operated in 2000 (group A) and 66 (59 patients: F/M: 1.5) in 2010 (group B). An associated condition was determined in 81 cases (75.5 %): mainly herpetic uveitis (9), sarcoidosis (7), tuberculosis (10), birdshot chorioretinopathy (7), Behcet's disease (8), spondyloarthropathy (10), Vogt‐Koyanagi‐Harada disease (5), Fuchs heterochromic iridocyclitis (8). Delay between onset of uveitis and surgery was 58.86 months in group A and 111.68 months in group B (p&lt;0.01). Mean BCVA postoperatively improved from logMAR 0.927 and 0.731 to 0.439 and 0,242 in groups A and B, respectively. Conclusion During a 10‐year period, management of uveitis has dramatically improved. Better management of ocular inflammation based on biologic agents may delay cataractogenesis in active patients.</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/j.1755-3768.2013.S071.x</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Cataracts ; Eye surgery ; Ophthalmology ; Surgery</subject><ispartof>Acta ophthalmologica (Oxford, England), 2013-08, Vol.91 (s252), p.0-0</ispartof><rights>2013 Acta Ophthalmologica</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1755-3768.2013.S071.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45575,46833</link.rule.ids></links><search><creatorcontrib>REMOND, A</creatorcontrib><creatorcontrib>LE HOANG, P</creatorcontrib><creatorcontrib>BODAGHI, B</creatorcontrib><title>Cataractogenesis and surgical outcome in patients with uveitis</title><title>Acta ophthalmologica (Oxford, England)</title><description>Purpose To compare the risk of cataract development, the surgical management and the prevalence of complications in 2 groups of patients with uveitis treated in 2000 and 2010. Methods Retrospective study of patients with uveitis referred to an academic centre for the diagnosis and treatment of uveitis. An extensive work‐up based on clinical presentation was performed when necessary. Corticosteroids were the mainstay of therapy in 2000 but new immunosuppressive molecules and biologics were used in 2010. Two groups were analyzed based on the year of cataract surgery (group A:2000 and group B:2010). Demographic factors, delay between onset of uveitis and cataract surgery, improvement of visual acuity and major complications were studied. Phacoemulsification and intraocular lens implantation were performed in all cases respecting a 3‐month quiescence of uveitis and an efficient perioperative anti‐inflammatory regimen. Results The study included 125 eyes of 107 patients. 59 eyes (48 patients: F/M: 1.29) were operated in 2000 (group A) and 66 (59 patients: F/M: 1.5) in 2010 (group B). An associated condition was determined in 81 cases (75.5 %): mainly herpetic uveitis (9), sarcoidosis (7), tuberculosis (10), birdshot chorioretinopathy (7), Behcet's disease (8), spondyloarthropathy (10), Vogt‐Koyanagi‐Harada disease (5), Fuchs heterochromic iridocyclitis (8). Delay between onset of uveitis and surgery was 58.86 months in group A and 111.68 months in group B (p&lt;0.01). Mean BCVA postoperatively improved from logMAR 0.927 and 0.731 to 0.439 and 0,242 in groups A and B, respectively. Conclusion During a 10‐year period, management of uveitis has dramatically improved. Better management of ocular inflammation based on biologic agents may delay cataractogenesis in active patients.</description><subject>Cataracts</subject><subject>Eye surgery</subject><subject>Ophthalmology</subject><subject>Surgery</subject><issn>1755-375X</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNkN1LwzAUxYMoOKd_gwGfW5OmTVoQYQy_YLCHKfgW7vIxU7Z2Jqnb_ntbJnv2vtzD5Zx74IfQLSUp7ee-TqkoioQJXqYZoSxdEEHT_Rkane7nJ118XqKrEGpCOOU8H6HHKUTwoGK7Mo0JLmBoNA6dXzkFa9x2UbUbg12DtxCdaWLAOxe_cPdjXHThGl1YWAdz87fH6OP56X36mszmL2_TySxRVJQ00bktRa6JXgJhiuuMlUJoy7Q2VVXpzDCbAYU8E6zioIAA1VpYbpaW5QUAG6O749-tb787E6Ks2843faWkeVEWtCpF1rvE0aV8G4I3Vm6924A_SErkAEvWcgAhByhygCUHWHLfJx-OyZ1bm8N_Y3IyXwyK_QJbFnFB</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>REMOND, A</creator><creator>LE HOANG, P</creator><creator>BODAGHI, B</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>201308</creationdate><title>Cataractogenesis and surgical outcome in patients with uveitis</title><author>REMOND, A ; LE HOANG, P ; BODAGHI, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1781-d4f874d0dba03c6d23877df3dde999d2e3f2a1a427396aca0a1dd7f6ebf345aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Cataracts</topic><topic>Eye surgery</topic><topic>Ophthalmology</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>REMOND, A</creatorcontrib><creatorcontrib>LE HOANG, P</creatorcontrib><creatorcontrib>BODAGHI, B</creatorcontrib><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>REMOND, A</au><au>LE HOANG, P</au><au>BODAGHI, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cataractogenesis and surgical outcome in patients with uveitis</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><date>2013-08</date><risdate>2013</risdate><volume>91</volume><issue>s252</issue><spage>0</spage><epage>0</epage><pages>0-0</pages><issn>1755-375X</issn><eissn>1755-3768</eissn><abstract>Purpose To compare the risk of cataract development, the surgical management and the prevalence of complications in 2 groups of patients with uveitis treated in 2000 and 2010. Methods Retrospective study of patients with uveitis referred to an academic centre for the diagnosis and treatment of uveitis. An extensive work‐up based on clinical presentation was performed when necessary. Corticosteroids were the mainstay of therapy in 2000 but new immunosuppressive molecules and biologics were used in 2010. Two groups were analyzed based on the year of cataract surgery (group A:2000 and group B:2010). Demographic factors, delay between onset of uveitis and cataract surgery, improvement of visual acuity and major complications were studied. Phacoemulsification and intraocular lens implantation were performed in all cases respecting a 3‐month quiescence of uveitis and an efficient perioperative anti‐inflammatory regimen. Results The study included 125 eyes of 107 patients. 59 eyes (48 patients: F/M: 1.29) were operated in 2000 (group A) and 66 (59 patients: F/M: 1.5) in 2010 (group B). An associated condition was determined in 81 cases (75.5 %): mainly herpetic uveitis (9), sarcoidosis (7), tuberculosis (10), birdshot chorioretinopathy (7), Behcet's disease (8), spondyloarthropathy (10), Vogt‐Koyanagi‐Harada disease (5), Fuchs heterochromic iridocyclitis (8). Delay between onset of uveitis and surgery was 58.86 months in group A and 111.68 months in group B (p&lt;0.01). Mean BCVA postoperatively improved from logMAR 0.927 and 0.731 to 0.439 and 0,242 in groups A and B, respectively. Conclusion During a 10‐year period, management of uveitis has dramatically improved. Better management of ocular inflammation based on biologic agents may delay cataractogenesis in active patients.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><doi>10.1111/j.1755-3768.2013.S071.x</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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subjects Cataracts
Eye surgery
Ophthalmology
Surgery
title Cataractogenesis and surgical outcome in patients with uveitis
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