Landscape of somatic mutations and clonal evolution in mantle cell lymphoma

Mantle cell lymphoma (MCL) is an aggressive tumor, but a subset of patients may follow an indolent clinical course. To understand the mechanisms underlying this biological heterogeneity, we performed whole-genome and/or whole-exome sequencing on 29 MCL cases and their respective matched normal DNA,...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-11, Vol.110 (45), p.18250-18255
Hauptverfasser:	Beà, Sílvia, Valdés-Mas, Rafael, Navarro, Alba, Salaverria, Itziar, Martín-Garcia, David, Jares, Pedro, Giné, Eva, Pinyol, Magda, Royo, Cristina, Nadeu, Ferran, Conde, Laura, Juan, Manel, Clot, Guillem, Vizán, Pedro, Di Croce, Luciano, Puente, Diana A., López-Guerra, Mónica, Moros, Alexandra, Roue, Gael, Aymerich, Marta, Villamor, Neus, Colomo, Lluís, Martínez, Antonio, Valera, Alexandra, Martín-Subero, José I., Amador, Virginia, Hernández, Luis, Rozman, Maria, Enjuanes, Anna, Forcada, Pilar, Muntañola, Ana, Hartmann, Elena M., Calasanz, María J., Rosenwald, Andreas, Ott, German, Hernández-Rivas, Jesús M., Klapper, Wolfram, Siebert, Reiner, Wiestner, Adrian, Wilson, Wyndham H., Colomer, Dolors, López-Guillermo, Armando, López-Otín, Carlos, Puente, Xose S., Campo, Elías
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia Telangiectasia Mutated Proteins - genetics Base Sequence Biological Sciences Blood Cell lines Chromatin Clonal Evolution - genetics Cloning Cyclin D1 - genetics cyclins disease course DNA Evolution Genes Genetic mutation Genetic Variation Genome, Human - genetics Genome-Wide Association Study Genomics - methods Genotype High-Throughput Nucleotide Sequencing Humans Lymphoma Lymphoma, Mantle-Cell - genetics Lymphoma, Mantle-Cell - physiopathology Mantle cell lymphoma Medical diagnosis Microarray Analysis Molecular Sequence Data Mutation Mutation - genetics neoplasm cells neoplasms Pathogenesis patients pro-apoptotic proteins prognosis Receptor, Notch2 - genetics Sequencing Somatic mutation T cell receptors Toll-like receptor 2 Toll-Like Receptor 2 - genetics Tumors
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