Prevention of Oxidative DNA Degradation by Copper-Binding Peptides
Free divalent ions of copper (Cu) are capable of generating radical species such as hydroxyl radicals in the presence of hydrogen peroxide or ascorbic acid through Harbor-Weiss-like reactions under physiological conditions. It has been reported that radical-mediated damage to DNA molecules in animal...
Gespeichert in:
| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2011, Vol.75 (7), p.1377-1379 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1379 |
|---|---|
| container_issue | 7 |
| container_start_page | 1377 |
| container_title | Bioscience, biotechnology, and biochemistry |
| container_volume | 75 |
| creator | YOKAWA, Ken KAGENISHI, Tomoko KAWANO, Tomonori |
| description | Free divalent ions of copper (Cu) are capable of generating radical species such as hydroxyl radicals in the presence of hydrogen peroxide or ascorbic acid through Harbor-Weiss-like reactions under physiological conditions. It has been reported that radical-mediated damage to DNA molecules in animal cells leads to programmed cell death. Hence it is important to seek for methods to prevent Cu-mediated DNA damage. In this study we identified on effect of Cu binding of short peptides (chiefly Gly-Gly-His tripeptide) in the prevention of DNA degradation caused by Cu-mediated reactions in the presence of hydrogen peroxide and of ascorbic acid. |
| doi_str_mv | 10.1271/bbb.100900 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pasca</sourceid><recordid>TN_cdi_proquest_journals_1449851345</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>879105617</sourcerecordid><originalsourceid>FETCH-LOGICAL-c675t-aaa3c27ab793f94945791af7bac1520bdb9be410565219d93f38fbfa43d4ebd03</originalsourceid><addsrcrecordid>eNqF0U9LHDEUAPBQLHXd9tIPUAZEBGFs3iSZbI66aluQ6qE9h5dJIpHZyZjM2u63N7JrC0XoKYT88v4S8hHoKTQSPhtjToFSRekbMgPGZd0qLvfIjCpo6wUXsE8Ocr6nxYCAd2S_AcmkAjYj57fJPbphCnGooq9ufgeLU3h01cX3s-rC3SV8vpdHs6mWcRxdqs_DYMNwV926cQrW5ffkrcc-uw-7c05-Xl3-WH6tr2--fFueXdddK8VUIyLrGolGKuYVV1yUCtBLgx2IhhprlHEcqGhFA8oWxBbeeOTMcmcsZXNyvI07pviwdnnSq5A71_c4uLjOeqFY07aN4P-XJXPJU4YwJ4f_yPu4TkNpQwPnaiHKOEVRJ1vVpZhzcl6PKawwbTRQ_bwCXVagtyso-NMu5NqsnP1DX2ZewNEOYO6w9wmHLuS_jgsFikFxYuvC4GNa4a-Yeqsn3PQxvXxirxTwBCP_nkA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1449851345</pqid></control><display><type>article</type><title>Prevention of Oxidative DNA Degradation by Copper-Binding Peptides</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>Open Access Titles of Japan</source><source>Free Full-Text Journals in Chemistry</source><creator>YOKAWA, Ken ; KAGENISHI, Tomoko ; KAWANO, Tomonori</creator><creatorcontrib>YOKAWA, Ken ; KAGENISHI, Tomoko ; KAWANO, Tomonori</creatorcontrib><description>Free divalent ions of copper (Cu) are capable of generating radical species such as hydroxyl radicals in the presence of hydrogen peroxide or ascorbic acid through Harbor-Weiss-like reactions under physiological conditions. It has been reported that radical-mediated damage to DNA molecules in animal cells leads to programmed cell death. Hence it is important to seek for methods to prevent Cu-mediated DNA damage. In this study we identified on effect of Cu binding of short peptides (chiefly Gly-Gly-His tripeptide) in the prevention of DNA degradation caused by Cu-mediated reactions in the presence of hydrogen peroxide and of ascorbic acid.</description><identifier>ISSN: 0916-8451</identifier><identifier>ISSN: 1347-6947</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.100900</identifier><identifier>PMID: 21737913</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>Ascorbic Acid - chemistry ; Ascorbic Acid - metabolism ; Biological and medical sciences ; Carrier Proteins - chemistry ; copper ; DNA - chemistry ; DNA - metabolism ; DNA Damage - drug effects ; DNA degradation ; Fundamental and applied biological sciences. Psychology ; Hydrogen Peroxide - chemistry ; Hydrogen Peroxide - metabolism ; Hydroxyl Radical - chemistry ; Hydroxyl Radical - metabolism ; Hydroxyl Radical - pharmacology ; Oligopeptides - chemistry ; Oligopeptides - pharmacology ; Oxidation-Reduction ; peptide ; reactive oxygen species ; Reactive Oxygen Species - chemistry ; Reactive Oxygen Species - metabolism</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2011, Vol.75 (7), p.1377-1379</ispartof><rights>2011 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2011</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c675t-aaa3c27ab793f94945791af7bac1520bdb9be410565219d93f38fbfa43d4ebd03</citedby><cites>FETCH-LOGICAL-c675t-aaa3c27ab793f94945791af7bac1520bdb9be410565219d93f38fbfa43d4ebd03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24591931$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21737913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YOKAWA, Ken</creatorcontrib><creatorcontrib>KAGENISHI, Tomoko</creatorcontrib><creatorcontrib>KAWANO, Tomonori</creatorcontrib><title>Prevention of Oxidative DNA Degradation by Copper-Binding Peptides</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>Free divalent ions of copper (Cu) are capable of generating radical species such as hydroxyl radicals in the presence of hydrogen peroxide or ascorbic acid through Harbor-Weiss-like reactions under physiological conditions. It has been reported that radical-mediated damage to DNA molecules in animal cells leads to programmed cell death. Hence it is important to seek for methods to prevent Cu-mediated DNA damage. In this study we identified on effect of Cu binding of short peptides (chiefly Gly-Gly-His tripeptide) in the prevention of DNA degradation caused by Cu-mediated reactions in the presence of hydrogen peroxide and of ascorbic acid.</description><subject>Ascorbic Acid - chemistry</subject><subject>Ascorbic Acid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - chemistry</subject><subject>copper</subject><subject>DNA - chemistry</subject><subject>DNA - metabolism</subject><subject>DNA Damage - drug effects</subject><subject>DNA degradation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hydrogen Peroxide - chemistry</subject><subject>Hydrogen Peroxide - metabolism</subject><subject>Hydroxyl Radical - chemistry</subject><subject>Hydroxyl Radical - metabolism</subject><subject>Hydroxyl Radical - pharmacology</subject><subject>Oligopeptides - chemistry</subject><subject>Oligopeptides - pharmacology</subject><subject>Oxidation-Reduction</subject><subject>peptide</subject><subject>reactive oxygen species</subject><subject>Reactive Oxygen Species - chemistry</subject><subject>Reactive Oxygen Species - metabolism</subject><issn>0916-8451</issn><issn>1347-6947</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U9LHDEUAPBQLHXd9tIPUAZEBGFs3iSZbI66aluQ6qE9h5dJIpHZyZjM2u63N7JrC0XoKYT88v4S8hHoKTQSPhtjToFSRekbMgPGZd0qLvfIjCpo6wUXsE8Ocr6nxYCAd2S_AcmkAjYj57fJPbphCnGooq9ufgeLU3h01cX3s-rC3SV8vpdHs6mWcRxdqs_DYMNwV926cQrW5ffkrcc-uw-7c05-Xl3-WH6tr2--fFueXdddK8VUIyLrGolGKuYVV1yUCtBLgx2IhhprlHEcqGhFA8oWxBbeeOTMcmcsZXNyvI07pviwdnnSq5A71_c4uLjOeqFY07aN4P-XJXPJU4YwJ4f_yPu4TkNpQwPnaiHKOEVRJ1vVpZhzcl6PKawwbTRQ_bwCXVagtyso-NMu5NqsnP1DX2ZewNEOYO6w9wmHLuS_jgsFikFxYuvC4GNa4a-Yeqsn3PQxvXxirxTwBCP_nkA</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>YOKAWA, Ken</creator><creator>KAGENISHI, Tomoko</creator><creator>KAWANO, Tomonori</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>2011</creationdate><title>Prevention of Oxidative DNA Degradation by Copper-Binding Peptides</title><author>YOKAWA, Ken ; KAGENISHI, Tomoko ; KAWANO, Tomonori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c675t-aaa3c27ab793f94945791af7bac1520bdb9be410565219d93f38fbfa43d4ebd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Ascorbic Acid - chemistry</topic><topic>Ascorbic Acid - metabolism</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - chemistry</topic><topic>copper</topic><topic>DNA - chemistry</topic><topic>DNA - metabolism</topic><topic>DNA Damage - drug effects</topic><topic>DNA degradation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hydrogen Peroxide - chemistry</topic><topic>Hydrogen Peroxide - metabolism</topic><topic>Hydroxyl Radical - chemistry</topic><topic>Hydroxyl Radical - metabolism</topic><topic>Hydroxyl Radical - pharmacology</topic><topic>Oligopeptides - chemistry</topic><topic>Oligopeptides - pharmacology</topic><topic>Oxidation-Reduction</topic><topic>peptide</topic><topic>reactive oxygen species</topic><topic>Reactive Oxygen Species - chemistry</topic><topic>Reactive Oxygen Species - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YOKAWA, Ken</creatorcontrib><creatorcontrib>KAGENISHI, Tomoko</creatorcontrib><creatorcontrib>KAWANO, Tomonori</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YOKAWA, Ken</au><au>KAGENISHI, Tomoko</au><au>KAWANO, Tomonori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevention of Oxidative DNA Degradation by Copper-Binding Peptides</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2011</date><risdate>2011</risdate><volume>75</volume><issue>7</issue><spage>1377</spage><epage>1379</epage><pages>1377-1379</pages><issn>0916-8451</issn><issn>1347-6947</issn><eissn>1347-6947</eissn><abstract>Free divalent ions of copper (Cu) are capable of generating radical species such as hydroxyl radicals in the presence of hydrogen peroxide or ascorbic acid through Harbor-Weiss-like reactions under physiological conditions. It has been reported that radical-mediated damage to DNA molecules in animal cells leads to programmed cell death. Hence it is important to seek for methods to prevent Cu-mediated DNA damage. In this study we identified on effect of Cu binding of short peptides (chiefly Gly-Gly-His tripeptide) in the prevention of DNA degradation caused by Cu-mediated reactions in the presence of hydrogen peroxide and of ascorbic acid.</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>21737913</pmid><doi>10.1271/bbb.100900</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-8451 |
| ispartof | Bioscience, biotechnology, and biochemistry, 2011, Vol.75 (7), p.1377-1379 |
| issn | 0916-8451 1347-6947 1347-6947 |
| language | eng |
| recordid | cdi_proquest_journals_1449851345 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Open Access Titles of Japan; Free Full-Text Journals in Chemistry |
| subjects | Ascorbic Acid - chemistry Ascorbic Acid - metabolism Biological and medical sciences Carrier Proteins - chemistry copper DNA - chemistry DNA - metabolism DNA Damage - drug effects DNA degradation Fundamental and applied biological sciences. Psychology Hydrogen Peroxide - chemistry Hydrogen Peroxide - metabolism Hydroxyl Radical - chemistry Hydroxyl Radical - metabolism Hydroxyl Radical - pharmacology Oligopeptides - chemistry Oligopeptides - pharmacology Oxidation-Reduction peptide reactive oxygen species Reactive Oxygen Species - chemistry Reactive Oxygen Species - metabolism |
| title | Prevention of Oxidative DNA Degradation by Copper-Binding Peptides |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T21%3A15%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevention%20of%20Oxidative%20DNA%20Degradation%20by%20Copper-Binding%20Peptides&rft.jtitle=Bioscience,%20biotechnology,%20and%20biochemistry&rft.au=YOKAWA,%20Ken&rft.date=2011&rft.volume=75&rft.issue=7&rft.spage=1377&rft.epage=1379&rft.pages=1377-1379&rft.issn=0916-8451&rft.eissn=1347-6947&rft_id=info:doi/10.1271/bbb.100900&rft_dat=%3Cproquest_pasca%3E879105617%3C/proquest_pasca%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1449851345&rft_id=info:pmid/21737913&rfr_iscdi=true |