Effects of a fermented barley extract on subjects with slightly high serum uric acid or mild hyperuricemia
The uric acid-lowering effect and safety of a fermented barley extract P (FBEP) prepared from barley-shochu distillery by-products were investigated in a randomized, placebo-controlled, parallel-group, double-blinded study. A total of 111 subjects with serum uric acid levels of 6.0-7.9 mg/dl were pr...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2010, Vol.74 (4), p.828-834 |
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| container_title | Bioscience, biotechnology, and biochemistry |
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| creator | Hokazono, H., Sanwa Shurui Co. Ltd., Usa, Oita (Japan) Omori, T Yamamoto, T Akaoka, I Ono, K |
| description | The uric acid-lowering effect and safety of a fermented barley extract P (FBEP) prepared from barley-shochu distillery by-products were investigated in a randomized, placebo-controlled, parallel-group, double-blinded study. A total of 111 subjects with serum uric acid levels of 6.0-7.9 mg/dl were provided with either a drink containing 2 g/d of FBEP (test group) or a placebo drink. After 12 weeks, the serum uric acid levels changed by −0.21±0.56 mg/dl in the test group, showing a significant decrease in comparison to those of the placebo group (+0.02±0.54 mg/dl). Additionally, the uric acid clearance in the test group showed a tendency to increase after 12 weeks more than in the placebo group (p=0.054). No abnormalities in the physical and clinical tests were observed, and no adverse diagnostic findings were attributed to the intake of the test meal. These results demonstrated the benefits and safety of the FBEP treatment to subjects with slightly high serum uric acid or mild hyperuricemia. |
| doi_str_mv | 10.1271/bbb.90936 |
| format | Article |
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Ltd., Usa, Oita (Japan) ; Omori, T ; Yamamoto, T ; Akaoka, I ; Ono, K</creator><creatorcontrib>Hokazono, H., Sanwa Shurui Co. Ltd., Usa, Oita (Japan) ; Omori, T ; Yamamoto, T ; Akaoka, I ; Ono, K</creatorcontrib><description>The uric acid-lowering effect and safety of a fermented barley extract P (FBEP) prepared from barley-shochu distillery by-products were investigated in a randomized, placebo-controlled, parallel-group, double-blinded study. A total of 111 subjects with serum uric acid levels of 6.0-7.9 mg/dl were provided with either a drink containing 2 g/d of FBEP (test group) or a placebo drink. After 12 weeks, the serum uric acid levels changed by −0.21±0.56 mg/dl in the test group, showing a significant decrease in comparison to those of the placebo group (+0.02±0.54 mg/dl). Additionally, the uric acid clearance in the test group showed a tendency to increase after 12 weeks more than in the placebo group (p=0.054). No abnormalities in the physical and clinical tests were observed, and no adverse diagnostic findings were attributed to the intake of the test meal. These results demonstrated the benefits and safety of the FBEP treatment to subjects with slightly high serum uric acid or mild hyperuricemia.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.90936</identifier><identifier>PMID: 20378966</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>ACIDE URIQUE ; ACIDO URICO ; Adult ; BARLEY ; Biological and medical sciences ; CEBADA ; DIAGNOSIS ; DIAGNOSTIC ; DIAGNOSTICO ; Dosage Forms ; EPIDEMIOLOGIA ; EPIDEMIOLOGIE ; EPIDEMIOLOGY ; EXTRACTOS ; EXTRACTS ; EXTRAIT ; Female ; FERMENTACION ; FERMENTATION ; Fundamental and applied biological sciences. Psychology ; GOTA ; GOUT ; GOUTTE ; Hordeum ; Hordeum vulgare ; http://www.fao.org/aos/agrovoc#c_16431 ; http://www.fao.org/aos/agrovoc#c_2238 ; http://www.fao.org/aos/agrovoc#c_2615 ; http://www.fao.org/aos/agrovoc#c_2767 ; http://www.fao.org/aos/agrovoc#c_2855 ; http://www.fao.org/aos/agrovoc#c_8097 ; http://www.fao.org/aos/agrovoc#c_823 ; Humans ; hyperuricemia ; Hyperuricemia - blood ; Hyperuricemia - drug therapy ; Male ; Middle Aged ; ORGE ; Safety ; shochu distillery by-product ; URIC ACID ; Uric Acid - blood ; Young Adult</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2010, Vol.74 (4), p.828-834</ispartof><rights>2010 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2010</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c566t-405fba4a60ade0da488f406f3db50bf7d0a6b00601f9df6082778d408adb9e8b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23227026$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20378966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hokazono, H., Sanwa Shurui Co. Ltd., Usa, Oita (Japan)</creatorcontrib><creatorcontrib>Omori, T</creatorcontrib><creatorcontrib>Yamamoto, T</creatorcontrib><creatorcontrib>Akaoka, I</creatorcontrib><creatorcontrib>Ono, K</creatorcontrib><title>Effects of a fermented barley extract on subjects with slightly high serum uric acid or mild hyperuricemia</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>The uric acid-lowering effect and safety of a fermented barley extract P (FBEP) prepared from barley-shochu distillery by-products were investigated in a randomized, placebo-controlled, parallel-group, double-blinded study. A total of 111 subjects with serum uric acid levels of 6.0-7.9 mg/dl were provided with either a drink containing 2 g/d of FBEP (test group) or a placebo drink. After 12 weeks, the serum uric acid levels changed by −0.21±0.56 mg/dl in the test group, showing a significant decrease in comparison to those of the placebo group (+0.02±0.54 mg/dl). Additionally, the uric acid clearance in the test group showed a tendency to increase after 12 weeks more than in the placebo group (p=0.054). No abnormalities in the physical and clinical tests were observed, and no adverse diagnostic findings were attributed to the intake of the test meal. These results demonstrated the benefits and safety of the FBEP treatment to subjects with slightly high serum uric acid or mild hyperuricemia.</description><subject>ACIDE URIQUE</subject><subject>ACIDO URICO</subject><subject>Adult</subject><subject>BARLEY</subject><subject>Biological and medical sciences</subject><subject>CEBADA</subject><subject>DIAGNOSIS</subject><subject>DIAGNOSTIC</subject><subject>DIAGNOSTICO</subject><subject>Dosage Forms</subject><subject>EPIDEMIOLOGIA</subject><subject>EPIDEMIOLOGIE</subject><subject>EPIDEMIOLOGY</subject><subject>EXTRACTOS</subject><subject>EXTRACTS</subject><subject>EXTRAIT</subject><subject>Female</subject><subject>FERMENTACION</subject><subject>FERMENTATION</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GOTA</subject><subject>GOUT</subject><subject>GOUTTE</subject><subject>Hordeum</subject><subject>Hordeum vulgare</subject><subject>http://www.fao.org/aos/agrovoc#c_16431</subject><subject>http://www.fao.org/aos/agrovoc#c_2238</subject><subject>http://www.fao.org/aos/agrovoc#c_2615</subject><subject>http://www.fao.org/aos/agrovoc#c_2767</subject><subject>http://www.fao.org/aos/agrovoc#c_2855</subject><subject>http://www.fao.org/aos/agrovoc#c_8097</subject><subject>http://www.fao.org/aos/agrovoc#c_823</subject><subject>Humans</subject><subject>hyperuricemia</subject><subject>Hyperuricemia - blood</subject><subject>Hyperuricemia - drug therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>ORGE</subject><subject>Safety</subject><subject>shochu distillery by-product</subject><subject>URIC ACID</subject><subject>Uric Acid - blood</subject><subject>Young Adult</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0k2LFDEQBuAgijuOHvwBSkBEPMxa6U4n6eOyrF8s6EHPodJJdnpId8akm7X_vZmdWQURPBVUnqoQ3hDynME5qyR7Z4w5b6GtxQOyYjWXG9Fy-ZCsoGVio3jDzsiTnHcApdGwx-SsglqqVogV2V1577op0-gpUu_S4MbJWWowBbdQ93NK2E00jjTPZncnb_tpS3Pob7ZTWOi2VJpdmgc6p76j2PWWxkSHPli6XfblpLTd0ONT8shjyO7Zqa7J9_dX3y4_bq6_fPh0eXG96Rohpg2HxhvkKACtA4tcKc9B-NqaBoyXFlAYAAHMt9YLUJWUynJQaE3rlKnX5M1x7z7FH7PLkx763LkQcHRxzloqyVpZMf5_Wddtw5Q6yFd_yV2c01ieoRnnreIcCl6Tt0fVpZhzcl7vUz9gWjQDfUhKl6T0XVLFvjxtnM3g7G95H00Br08Ac4fBJxy7Pv9xdVVJqA6OH10_-pgGvI0pWD3hEmK6H6r_df-L45jHqPEmFfX5awWsfJKKSVb_AmfZtgc</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Hokazono, H., Sanwa Shurui Co. 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Ltd., Usa, Oita (Japan) ; Omori, T ; Yamamoto, T ; Akaoka, I ; Ono, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c566t-405fba4a60ade0da488f406f3db50bf7d0a6b00601f9df6082778d408adb9e8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>ACIDE URIQUE</topic><topic>ACIDO URICO</topic><topic>Adult</topic><topic>BARLEY</topic><topic>Biological and medical sciences</topic><topic>CEBADA</topic><topic>DIAGNOSIS</topic><topic>DIAGNOSTIC</topic><topic>DIAGNOSTICO</topic><topic>Dosage Forms</topic><topic>EPIDEMIOLOGIA</topic><topic>EPIDEMIOLOGIE</topic><topic>EPIDEMIOLOGY</topic><topic>EXTRACTOS</topic><topic>EXTRACTS</topic><topic>EXTRAIT</topic><topic>Female</topic><topic>FERMENTACION</topic><topic>FERMENTATION</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GOTA</topic><topic>GOUT</topic><topic>GOUTTE</topic><topic>Hordeum</topic><topic>Hordeum vulgare</topic><topic>http://www.fao.org/aos/agrovoc#c_16431</topic><topic>http://www.fao.org/aos/agrovoc#c_2238</topic><topic>http://www.fao.org/aos/agrovoc#c_2615</topic><topic>http://www.fao.org/aos/agrovoc#c_2767</topic><topic>http://www.fao.org/aos/agrovoc#c_2855</topic><topic>http://www.fao.org/aos/agrovoc#c_8097</topic><topic>http://www.fao.org/aos/agrovoc#c_823</topic><topic>Humans</topic><topic>hyperuricemia</topic><topic>Hyperuricemia - blood</topic><topic>Hyperuricemia - drug therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>ORGE</topic><topic>Safety</topic><topic>shochu distillery by-product</topic><topic>URIC ACID</topic><topic>Uric Acid - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hokazono, H., Sanwa Shurui Co. Ltd., Usa, Oita (Japan)</creatorcontrib><creatorcontrib>Omori, T</creatorcontrib><creatorcontrib>Yamamoto, T</creatorcontrib><creatorcontrib>Akaoka, I</creatorcontrib><creatorcontrib>Ono, K</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hokazono, H., Sanwa Shurui Co. Ltd., Usa, Oita (Japan)</au><au>Omori, T</au><au>Yamamoto, T</au><au>Akaoka, I</au><au>Ono, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of a fermented barley extract on subjects with slightly high serum uric acid or mild hyperuricemia</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2010</date><risdate>2010</risdate><volume>74</volume><issue>4</issue><spage>828</spage><epage>834</epage><pages>828-834</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>The uric acid-lowering effect and safety of a fermented barley extract P (FBEP) prepared from barley-shochu distillery by-products were investigated in a randomized, placebo-controlled, parallel-group, double-blinded study. A total of 111 subjects with serum uric acid levels of 6.0-7.9 mg/dl were provided with either a drink containing 2 g/d of FBEP (test group) or a placebo drink. After 12 weeks, the serum uric acid levels changed by −0.21±0.56 mg/dl in the test group, showing a significant decrease in comparison to those of the placebo group (+0.02±0.54 mg/dl). Additionally, the uric acid clearance in the test group showed a tendency to increase after 12 weeks more than in the placebo group (p=0.054). No abnormalities in the physical and clinical tests were observed, and no adverse diagnostic findings were attributed to the intake of the test meal. These results demonstrated the benefits and safety of the FBEP treatment to subjects with slightly high serum uric acid or mild hyperuricemia.</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>20378966</pmid><doi>10.1271/bbb.90936</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Open Access Titles of Japan; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | ACIDE URIQUE ACIDO URICO Adult BARLEY Biological and medical sciences CEBADA DIAGNOSIS DIAGNOSTIC DIAGNOSTICO Dosage Forms EPIDEMIOLOGIA EPIDEMIOLOGIE EPIDEMIOLOGY EXTRACTOS EXTRACTS EXTRAIT Female FERMENTACION FERMENTATION Fundamental and applied biological sciences. Psychology GOTA GOUT GOUTTE Hordeum Hordeum vulgare http://www.fao.org/aos/agrovoc#c_16431 http://www.fao.org/aos/agrovoc#c_2238 http://www.fao.org/aos/agrovoc#c_2615 http://www.fao.org/aos/agrovoc#c_2767 http://www.fao.org/aos/agrovoc#c_2855 http://www.fao.org/aos/agrovoc#c_8097 http://www.fao.org/aos/agrovoc#c_823 Humans hyperuricemia Hyperuricemia - blood Hyperuricemia - drug therapy Male Middle Aged ORGE Safety shochu distillery by-product URIC ACID Uric Acid - blood Young Adult |
| title | Effects of a fermented barley extract on subjects with slightly high serum uric acid or mild hyperuricemia |
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