Antioxidant combination inhibits reactive oxygen species mediated damage
We examined the preventive activity of naturally occurring antioxidants against three reactive oxygen species using a protein degradation assay. The hydroxyl, hypochlorite, and peroxynitrite radicals are typical reactive oxygen species generated in human body. Previously, we found that hydrophobic b...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2008-12, Vol.72 (12), p.3100-3106 |
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| container_title | Bioscience, biotechnology, and biochemistry |
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| creator | Yanai, N.(National Food Research Inst., Tsukuba, Ibaraki (Japan)) Shiotani, S Hagiwara, S Nabetani, H Nakajima, M |
| description | We examined the preventive activity of naturally occurring antioxidants against three reactive oxygen species using a protein degradation assay. The hydroxyl, hypochlorite, and peroxynitrite radicals are typical reactive oxygen species generated in human body. Previously, we found that hydrophobic botanical antioxidants exhibited specific antioxidant activity against hydroxyl radicals, whereas anserine and carnosine mixture, purified from chicken extract and vitamin C, exhibited antioxidant activities against hypochlorite and peroxynitrite radicals respectively. Since ethanol, used as a solvent in the experiments, also showed an antioxidant action against the hydroxyl radical, we reassessed antioxidant activities using aqueous solutions of botanical antioxidants. Among the seven hydrophobic antioxidants examined, ferulic acid exhibited the strongest antioxidant activity against the hydroxyl radical. An antioxidant preparation of anserine-carnosine mixture, vitamin C, and ferulic acid prevented oxidative stress by reactive oxygen species. Loss of deformability in human erythrocytes and protein degradation caused by reactive oxygen species were completely inhibited. |
| doi_str_mv | 10.1271/bbb.80159 |
| format | Article |
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The hydroxyl, hypochlorite, and peroxynitrite radicals are typical reactive oxygen species generated in human body. Previously, we found that hydrophobic botanical antioxidants exhibited specific antioxidant activity against hydroxyl radicals, whereas anserine and carnosine mixture, purified from chicken extract and vitamin C, exhibited antioxidant activities against hypochlorite and peroxynitrite radicals respectively. Since ethanol, used as a solvent in the experiments, also showed an antioxidant action against the hydroxyl radical, we reassessed antioxidant activities using aqueous solutions of botanical antioxidants. Among the seven hydrophobic antioxidants examined, ferulic acid exhibited the strongest antioxidant activity against the hydroxyl radical. An antioxidant preparation of anserine-carnosine mixture, vitamin C, and ferulic acid prevented oxidative stress by reactive oxygen species. Loss of deformability in human erythrocytes and protein degradation caused by reactive oxygen species were completely inhibited.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.80159</identifier><identifier>PMID: 19060409</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>ACIDE ASCORBIQUE ; ACIDE FERULIQUE ; ACIDO ASCORBICO ; ACIDO FERULICO ; anserine-carnosine ; antioxidant combination ; ANTIOXIDANTES ; ANTIOXIDANTS ; Antioxidants - pharmacology ; ANTIOXYDANT ; ASCORBIC ACID ; Biological and medical sciences ; Drug Combinations ; Egg Proteins - metabolism ; Erythrocyte Deformability - drug effects ; ESPECIES DE OXIGENO REACTIVO ; FERULIC ACID ; Fundamental and applied biological sciences. Psychology ; GENERO HUMANO ; GENRE HUMAIN ; Humans ; MANKIND ; Oxidative Stress - drug effects ; REACTIVE OXYGEN SPECIES ; Reactive Oxygen Species - antagonists & inhibitors ; Reactive Oxygen Species - metabolism ; TOCOFEROLES ; TOCOPHEROL ; TOCOPHEROLS</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2008-12, Vol.72 (12), p.3100-3106</ispartof><rights>2008 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2008</rights><rights>2009 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c690t-eeb9e22298dbe301b0930473269aa42f5957412c837a1be0d096f766e1b0229d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21079862$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19060409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yanai, N.(National Food Research Inst., Tsukuba, Ibaraki (Japan))</creatorcontrib><creatorcontrib>Shiotani, S</creatorcontrib><creatorcontrib>Hagiwara, S</creatorcontrib><creatorcontrib>Nabetani, H</creatorcontrib><creatorcontrib>Nakajima, M</creatorcontrib><title>Antioxidant combination inhibits reactive oxygen species mediated damage</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>We examined the preventive activity of naturally occurring antioxidants against three reactive oxygen species using a protein degradation assay. The hydroxyl, hypochlorite, and peroxynitrite radicals are typical reactive oxygen species generated in human body. Previously, we found that hydrophobic botanical antioxidants exhibited specific antioxidant activity against hydroxyl radicals, whereas anserine and carnosine mixture, purified from chicken extract and vitamin C, exhibited antioxidant activities against hypochlorite and peroxynitrite radicals respectively. Since ethanol, used as a solvent in the experiments, also showed an antioxidant action against the hydroxyl radical, we reassessed antioxidant activities using aqueous solutions of botanical antioxidants. Among the seven hydrophobic antioxidants examined, ferulic acid exhibited the strongest antioxidant activity against the hydroxyl radical. An antioxidant preparation of anserine-carnosine mixture, vitamin C, and ferulic acid prevented oxidative stress by reactive oxygen species. Loss of deformability in human erythrocytes and protein degradation caused by reactive oxygen species were completely inhibited.</description><subject>ACIDE ASCORBIQUE</subject><subject>ACIDE FERULIQUE</subject><subject>ACIDO ASCORBICO</subject><subject>ACIDO FERULICO</subject><subject>anserine-carnosine</subject><subject>antioxidant combination</subject><subject>ANTIOXIDANTES</subject><subject>ANTIOXIDANTS</subject><subject>Antioxidants - pharmacology</subject><subject>ANTIOXYDANT</subject><subject>ASCORBIC ACID</subject><subject>Biological and medical sciences</subject><subject>Drug Combinations</subject><subject>Egg Proteins - metabolism</subject><subject>Erythrocyte Deformability - drug effects</subject><subject>ESPECIES DE OXIGENO REACTIVO</subject><subject>FERULIC ACID</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GENERO HUMANO</subject><subject>GENRE HUMAIN</subject><subject>Humans</subject><subject>MANKIND</subject><subject>Oxidative Stress - drug effects</subject><subject>REACTIVE OXYGEN SPECIES</subject><subject>Reactive Oxygen Species - antagonists & inhibitors</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>TOCOFEROLES</subject><subject>TOCOPHEROL</subject><subject>TOCOPHEROLS</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFklFrFDEUhYModq0--AOUAVHwYepNJpNMHktRWynUB30ONzN31pSZZE1mtfvvTd3Vggh9Cly-cy_nnDD2nMMJF5q_c86ddMBb84CteCN1rYzUD9kKDFd1J1t-xJ7kfA1QBi1_zI64AQUSzIqdn4bFxxs_YFiqPs7OByyDUPnwzTu_5CoR9ov_QVW82a0pVHlDvadczTR4XGioBpxxTU_ZoxGnTM8O7zH7-uH9l7Pz-vLq48XZ6WXdKwNLTeQMCSFMNzhqgDswDUjdCGUQpRhb02rJRd81GrkjGMCoUStFhSyqoTlmb_Z7Nyl-31Je7OxzT9OEgeI2W2VMccfVvaCAputa4AV89Q94HbcpFBOWS2k6WZIShXq7p_oUc0402k3yM6ad5WBvW7ClBfu7hcK-PGzcuhLTHXmIvQCvDwDmHqcxYeh9_ssJDtp06vao3HM-jDHN-DOmabAL7qaY_oia_91_sZeNGC2uU6E-fRal_fIDdPH9Cy5EqCc</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Yanai, N.(National Food Research Inst., Tsukuba, Ibaraki (Japan))</creator><creator>Shiotani, S</creator><creator>Hagiwara, S</creator><creator>Nabetani, H</creator><creator>Nakajima, M</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><general>Oxford University Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20081201</creationdate><title>Antioxidant combination inhibits reactive oxygen species mediated damage</title><author>Yanai, N.(National Food Research Inst., Tsukuba, Ibaraki (Japan)) ; Shiotani, S ; Hagiwara, S ; Nabetani, H ; Nakajima, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c690t-eeb9e22298dbe301b0930473269aa42f5957412c837a1be0d096f766e1b0229d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>ACIDE ASCORBIQUE</topic><topic>ACIDE FERULIQUE</topic><topic>ACIDO ASCORBICO</topic><topic>ACIDO FERULICO</topic><topic>anserine-carnosine</topic><topic>antioxidant combination</topic><topic>ANTIOXIDANTES</topic><topic>ANTIOXIDANTS</topic><topic>Antioxidants - pharmacology</topic><topic>ANTIOXYDANT</topic><topic>ASCORBIC ACID</topic><topic>Biological and medical sciences</topic><topic>Drug Combinations</topic><topic>Egg Proteins - metabolism</topic><topic>Erythrocyte Deformability - drug effects</topic><topic>ESPECIES DE OXIGENO REACTIVO</topic><topic>FERULIC ACID</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GENERO HUMANO</topic><topic>GENRE HUMAIN</topic><topic>Humans</topic><topic>MANKIND</topic><topic>Oxidative Stress - drug effects</topic><topic>REACTIVE OXYGEN SPECIES</topic><topic>Reactive Oxygen Species - antagonists & inhibitors</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>TOCOFEROLES</topic><topic>TOCOPHEROL</topic><topic>TOCOPHEROLS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yanai, N.(National Food Research Inst., Tsukuba, Ibaraki (Japan))</creatorcontrib><creatorcontrib>Shiotani, S</creatorcontrib><creatorcontrib>Hagiwara, S</creatorcontrib><creatorcontrib>Nabetani, H</creatorcontrib><creatorcontrib>Nakajima, M</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yanai, N.(National Food Research Inst., Tsukuba, Ibaraki (Japan))</au><au>Shiotani, S</au><au>Hagiwara, S</au><au>Nabetani, H</au><au>Nakajima, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant combination inhibits reactive oxygen species mediated damage</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>72</volume><issue>12</issue><spage>3100</spage><epage>3106</epage><pages>3100-3106</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>We examined the preventive activity of naturally occurring antioxidants against three reactive oxygen species using a protein degradation assay. The hydroxyl, hypochlorite, and peroxynitrite radicals are typical reactive oxygen species generated in human body. Previously, we found that hydrophobic botanical antioxidants exhibited specific antioxidant activity against hydroxyl radicals, whereas anserine and carnosine mixture, purified from chicken extract and vitamin C, exhibited antioxidant activities against hypochlorite and peroxynitrite radicals respectively. Since ethanol, used as a solvent in the experiments, also showed an antioxidant action against the hydroxyl radical, we reassessed antioxidant activities using aqueous solutions of botanical antioxidants. Among the seven hydrophobic antioxidants examined, ferulic acid exhibited the strongest antioxidant activity against the hydroxyl radical. An antioxidant preparation of anserine-carnosine mixture, vitamin C, and ferulic acid prevented oxidative stress by reactive oxygen species. Loss of deformability in human erythrocytes and protein degradation caused by reactive oxygen species were completely inhibited.</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>19060409</pmid><doi>10.1271/bbb.80159</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | ACIDE ASCORBIQUE ACIDE FERULIQUE ACIDO ASCORBICO ACIDO FERULICO anserine-carnosine antioxidant combination ANTIOXIDANTES ANTIOXIDANTS Antioxidants - pharmacology ANTIOXYDANT ASCORBIC ACID Biological and medical sciences Drug Combinations Egg Proteins - metabolism Erythrocyte Deformability - drug effects ESPECIES DE OXIGENO REACTIVO FERULIC ACID Fundamental and applied biological sciences. Psychology GENERO HUMANO GENRE HUMAIN Humans MANKIND Oxidative Stress - drug effects REACTIVE OXYGEN SPECIES Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism TOCOFEROLES TOCOPHEROL TOCOPHEROLS |
| title | Antioxidant combination inhibits reactive oxygen species mediated damage |
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