Enhanced valine production in Corynebacterium glutamicum with defective H(+)-ATPase and C-terminal truncated acetohydroxyacid synthase

We have reported increased glutamate production by a mutant of Corynebacterium glutamicum ATCC14067 (strain F172-8) with reduced Hsup(+)-ATPase activity under biotin-limiting culture conditions (Aoki et al. Biosci. Biotechnol. Biochem., 69, 1466-1472 (2005)). In the present study, we examined valine...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2008-11, Vol.72 (11), p.2959-2965
Hauptverfasser:	Wada, M.(Hokkaido Univ., Sapporo (Japan)), Hijikata, N, Aoki, R, Takesue, N, Yokota, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetolactate Synthase - chemistry Acetolactate Synthase - genetics Acetolactate Synthase - metabolism ATPASA ATPASE Biological and medical sciences BIOSINTESIS BIOSYNTHESE BIOSYNTHESIS CORYNEBACTERIUM Corynebacterium glutamicum Corynebacterium glutamicum - enzymology Corynebacterium glutamicum - genetics Corynebacterium glutamicum - metabolism feedback-insensitive Fundamental and applied biological sciences. Psychology Gene Deletion Genetic Engineering Ketol-Acid Reductoisomerase - genetics LIGASAS LIGASE LIGASES MUTANT MUTANTES MUTANTS Proton-Translocating ATPases - genetics Proton-Translocating ATPases - metabolism VALINA VALINE Valine - biosynthesis valine production
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