Effect of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on the susceptibility to Listeria infection
We studied the effect of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the susceptibility to Listeria infection of offspring in C57BL/6NCji mice. The offspring were nursed by TCDD-treated dams and exposed to TCDD from birth to weaning via milk. The exposure had little effect...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2003-01, Vol.67 (1), p.89-93 |
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| container_title | Bioscience, biotechnology, and biochemistry |
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| creator | Sugita Konishi, Y. (National Inst. of Health Science, Tokyo (Japan)) Kobayashi, K Naito, H Miura, K Suzuki, Y |
| description | We studied the effect of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the susceptibility to Listeria infection of offspring in C57BL/6NCji mice. The offspring were nursed by TCDD-treated dams and exposed to TCDD from birth to weaning via milk. The exposure had little effect on the weights of immune organs and the spleen or the thymus cell population in the dams and offspring, but it enhanced the production of tumor necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ) in the serum after Listeria infection. The clearance of Listeria monocytogenes from the spleen was impaired in the offspring. These results suggest that the exposure to TCDD of the offspring via milk disrupted the host resistance of the offspring, even though the main immune parameters were unchanged. |
| doi_str_mv | 10.1271/bbb.67.89 |
| format | Article |
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(National Inst. of Health Science, Tokyo (Japan)) ; Kobayashi, K ; Naito, H ; Miura, K ; Suzuki, Y</creator><creatorcontrib>Sugita Konishi, Y. (National Inst. of Health Science, Tokyo (Japan)) ; Kobayashi, K ; Naito, H ; Miura, K ; Suzuki, Y</creatorcontrib><description>We studied the effect of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the susceptibility to Listeria infection of offspring in C57BL/6NCji mice. The offspring were nursed by TCDD-treated dams and exposed to TCDD from birth to weaning via milk. The exposure had little effect on the weights of immune organs and the spleen or the thymus cell population in the dams and offspring, but it enhanced the production of tumor necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ) in the serum after Listeria infection. The clearance of Listeria monocytogenes from the spleen was impaired in the offspring. These results suggest that the exposure to TCDD of the offspring via milk disrupted the host resistance of the offspring, even though the main immune parameters were unchanged.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.67.89</identifier><identifier>PMID: 12619678</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>Animals ; Biological and medical sciences ; Cytokines - metabolism ; DIOXINS ; DISEASE RESISTANCE ; drinking water ; Environmental Pollutants - toxicity ; Female ; Flow Cytometry ; Fundamental and applied biological sciences. 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(National Inst. of Health Science, Tokyo (Japan))</creatorcontrib><creatorcontrib>Kobayashi, K</creatorcontrib><creatorcontrib>Naito, H</creatorcontrib><creatorcontrib>Miura, K</creatorcontrib><creatorcontrib>Suzuki, Y</creatorcontrib><title>Effect of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on the susceptibility to Listeria infection</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>We studied the effect of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the susceptibility to Listeria infection of offspring in C57BL/6NCji mice. The offspring were nursed by TCDD-treated dams and exposed to TCDD from birth to weaning via milk. The exposure had little effect on the weights of immune organs and the spleen or the thymus cell population in the dams and offspring, but it enhanced the production of tumor necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ) in the serum after Listeria infection. The clearance of Listeria monocytogenes from the spleen was impaired in the offspring. These results suggest that the exposure to TCDD of the offspring via milk disrupted the host resistance of the offspring, even though the main immune parameters were unchanged.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cytokines - metabolism</subject><subject>DIOXINS</subject><subject>DISEASE RESISTANCE</subject><subject>drinking water</subject><subject>Environmental Pollutants - toxicity</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>INFECTION</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interferon-gamma - genetics</subject><subject>LACTATION</subject><subject>Lactation - physiology</subject><subject>LISTERIA</subject><subject>Listeria monocytogenes</subject><subject>Listeriosis - immunology</subject><subject>Listeriosis - microbiology</subject><subject>Male</subject><subject>MICE</subject><subject>Mice, Inbred C57BL</subject><subject>MILK</subject><subject>Milk - chemistry</subject><subject>Polychlorinated Dibenzodioxins - toxicity</subject><subject>Pregnancy</subject><subject>Sex Characteristics</subject><subject>Spleen - drug effects</subject><subject>Spleen - immunology</subject><subject>suckling mice</subject><subject>TCDD</subject><subject>Thymus Gland - drug effects</subject><subject>Thymus Gland - immunology</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkV1rFDEYhYModlu98AcoA6Ig7KzJ5PtSSv1iQS_0OmTyYVOyk2mSwa6_vll2pSBCIBCec9435wDwAsENGjh6P47jhvGNkI_ACmHCeyYJfwxWUCLWC0LRGTgv5QbC9kDRU3CGBoYk42IFbq-8d6Z2yXdRm6prSJOOnbubU1my62rqhjVe87Xoq6tZm-uYcrJhdNOf1M-9DekuTF2aunrturIU4-YaxhBD3R_E21Cqy0F3YTrMae7PwBOvY3HPT_cF-Pnx6sfl53777dOXyw_b3lDBa4-Jx8gSyxBCUmLqBJR4sMzrQdPBQUONFsYaLg3xzFkJpaTU8xF7SARl-AK8PfrOOd0urlS1C227GPXk0lIUElwKJoYGvv4HvElLbik0hhBJKJYSNurdkTI5lZKdV3MOO533CkF1aEG1FhTjSsjGvjo5LuPO2QfyFHsD3pwAXYyOPuvJhPLAEdH2Yoc_kCPX0kt5p3-nHK2qet9K-CvC_5v_8ijzOin9Kzfq6_cBQtxOs8b3RBeqNw</recordid><startdate>20030101</startdate><enddate>20030101</enddate><creator>Sugita Konishi, Y. 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The exposure had little effect on the weights of immune organs and the spleen or the thymus cell population in the dams and offspring, but it enhanced the production of tumor necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ) in the serum after Listeria infection. The clearance of Listeria monocytogenes from the spleen was impaired in the offspring. These results suggest that the exposure to TCDD of the offspring via milk disrupted the host resistance of the offspring, even though the main immune parameters were unchanged.</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>12619678</pmid><doi>10.1271/bbb.67.89</doi><tpages>5</tpages></addata></record> |
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| source | J-STAGE Free; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Freely Accessible Japanese Titles; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Biological and medical sciences Cytokines - metabolism DIOXINS DISEASE RESISTANCE drinking water Environmental Pollutants - toxicity Female Flow Cytometry Fundamental and applied biological sciences. Psychology INFECTION Interferon-gamma - biosynthesis Interferon-gamma - genetics LACTATION Lactation - physiology LISTERIA Listeria monocytogenes Listeriosis - immunology Listeriosis - microbiology Male MICE Mice, Inbred C57BL MILK Milk - chemistry Polychlorinated Dibenzodioxins - toxicity Pregnancy Sex Characteristics Spleen - drug effects Spleen - immunology suckling mice TCDD Thymus Gland - drug effects Thymus Gland - immunology Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics |
| title | Effect of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on the susceptibility to Listeria infection |
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