In vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid in citrus fruits
The polymethoxyflavonoid (PMF), nobiletin (NOB), specifically occurs in citrus fruits, and is currently believed to be a promising anti-inflammatory and anti-tumor promoting agent. In the present study, we investigated the in vitro absorption and metabolism of NOB and compared them with those of the...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2001-01, Vol.65 (1), p.194-197 |
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| container_title | Bioscience, biotechnology, and biochemistry |
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| creator | Murakami, A. (Kinki Univ., Higashiosaka, Osaka (Japan)) Kuwahara, S Takahashi, Y Ito, C Furukawa, H Juichi, M Koshimizu, K Ohigashi, H |
| description | The polymethoxyflavonoid (PMF), nobiletin (NOB), specifically occurs in citrus fruits, and is currently believed to be a promising anti-inflammatory and anti-tumor promoting agent. In the present study, we investigated the in vitro absorption and metabolism of NOB and compared them with those of the polyhydroxyflavonoid (PHF), luteolin (LT). NOB preferentially accumulated in a differentiated Caco-2 cell monolayer, which is a model for small intestinal epithelial cells, while LT did not. Treatment of NOB with a rat liver S-9 mixture led to the formation of 3'-demethyl-NOB, while that of LT did not. We thus suggest that PMFs including NOB have properties distinct from those of general flavonoids for absorption and metabolism in vitro. |
| doi_str_mv | 10.1271/bbb.65.194 |
| format | Article |
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(Kinki Univ., Higashiosaka, Osaka (Japan)) ; Kuwahara, S ; Takahashi, Y ; Ito, C ; Furukawa, H ; Juichi, M ; Koshimizu, K ; Ohigashi, H</creator><creatorcontrib>Murakami, A. (Kinki Univ., Higashiosaka, Osaka (Japan)) ; Kuwahara, S ; Takahashi, Y ; Ito, C ; Furukawa, H ; Juichi, M ; Koshimizu, K ; Ohigashi, H</creatorcontrib><description>The polymethoxyflavonoid (PMF), nobiletin (NOB), specifically occurs in citrus fruits, and is currently believed to be a promising anti-inflammatory and anti-tumor promoting agent. In the present study, we investigated the in vitro absorption and metabolism of NOB and compared them with those of the polyhydroxyflavonoid (PHF), luteolin (LT). NOB preferentially accumulated in a differentiated Caco-2 cell monolayer, which is a model for small intestinal epithelial cells, while LT did not. Treatment of NOB with a rat liver S-9 mixture led to the formation of 3'-demethyl-NOB, while that of LT did not. We thus suggest that PMFs including NOB have properties distinct from those of general flavonoids for absorption and metabolism in vitro.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.65.194</identifier><identifier>PMID: 11272829</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>ABSORPTION ; Animals ; Anticarcinogenic Agents - metabolism ; ANTINEOPLASTIC AGENTS ; Biological and medical sciences ; Caco-2 Cells ; CELLS ; Citrus - chemistry ; CITRUS FRUITS ; Flavones ; FLAVONOIDS ; Flavonoids - chemistry ; Flavonoids - metabolism ; Flavonoids - pharmacokinetics ; General pharmacology ; Humans ; IN VITRO EXPERIMENTATION ; Intestinal Absorption ; Intestinal Mucosa - metabolism ; INTESTINES ; Liver - metabolism ; Luteolin ; Medical sciences ; METABOLISM ; Molecular Structure ; nobiletin ; Pharmacognosy. Homeopathy. 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(Kinki Univ., Higashiosaka, Osaka (Japan))</creatorcontrib><creatorcontrib>Kuwahara, S</creatorcontrib><creatorcontrib>Takahashi, Y</creatorcontrib><creatorcontrib>Ito, C</creatorcontrib><creatorcontrib>Furukawa, H</creatorcontrib><creatorcontrib>Juichi, M</creatorcontrib><creatorcontrib>Koshimizu, K</creatorcontrib><creatorcontrib>Ohigashi, H</creatorcontrib><title>In vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid in citrus fruits</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>The polymethoxyflavonoid (PMF), nobiletin (NOB), specifically occurs in citrus fruits, and is currently believed to be a promising anti-inflammatory and anti-tumor promoting agent. In the present study, we investigated the in vitro absorption and metabolism of NOB and compared them with those of the polyhydroxyflavonoid (PHF), luteolin (LT). NOB preferentially accumulated in a differentiated Caco-2 cell monolayer, which is a model for small intestinal epithelial cells, while LT did not. Treatment of NOB with a rat liver S-9 mixture led to the formation of 3'-demethyl-NOB, while that of LT did not. We thus suggest that PMFs including NOB have properties distinct from those of general flavonoids for absorption and metabolism in vitro.</description><subject>ABSORPTION</subject><subject>Animals</subject><subject>Anticarcinogenic Agents - metabolism</subject><subject>ANTINEOPLASTIC AGENTS</subject><subject>Biological and medical sciences</subject><subject>Caco-2 Cells</subject><subject>CELLS</subject><subject>Citrus - chemistry</subject><subject>CITRUS FRUITS</subject><subject>Flavones</subject><subject>FLAVONOIDS</subject><subject>Flavonoids - chemistry</subject><subject>Flavonoids - metabolism</subject><subject>Flavonoids - pharmacokinetics</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>IN VITRO EXPERIMENTATION</subject><subject>Intestinal Absorption</subject><subject>Intestinal Mucosa - metabolism</subject><subject>INTESTINES</subject><subject>Liver - metabolism</subject><subject>Luteolin</subject><subject>Medical sciences</subject><subject>METABOLISM</subject><subject>Molecular Structure</subject><subject>nobiletin</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>rat liver S-9 mixture</subject><subject>Rats</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0MGP1CAUBnBiNO7s6sW7hkTjwdiR11Jajmaz6ppN9KBnAhQcNhQq0NH572UzYzTGEwn5vQ_eh9ATIFtoB3ijlNqyfguc3kMb6OjQME6H-2hDOLBmpD2cofOcbwmpFz08RGdQ59qx5Ru0uw5470qKWKoc01JcDFiGCc-mSBW9yzOOFoeonDfFhddYYr0zc1yS2ZtQ3N7gJfpD5bv482C93McQ3YRdwLrmrhnbtLqSH6EHVvpsHp_OC_T13dWXyw_Nzaf315dvbxrNGCkNN6OaxpYMXcu5hN5YmKAlSvNBUtaZkZph4jAqaTTregUjnSi1WjPFGNCuu0Avj7lLit9Xk4uYXdbGexlMXLMYCKMdUF7h83_gbVxTqH8TQCmnlBJyF_fqqHSKOSdjxZLcLNNBABF37YvavmC9qO1X_OwUuarZTH_oqe4KXpyAzFp6m2TQLv8Vydu-7Svrj8wFG9Msf8TkJ1Hkwcf0e6b77_tPj3NWRiG_pco-fm4JgboJB979AiebqLc</recordid><startdate>20010101</startdate><enddate>20010101</enddate><creator>Murakami, A. 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(Kinki Univ., Higashiosaka, Osaka (Japan)) ; Kuwahara, S ; Takahashi, Y ; Ito, C ; Furukawa, H ; Juichi, M ; Koshimizu, K ; Ohigashi, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c660t-9e8bd82073299a15ef1d120bc97a463e84e7d918baec635b184d44fcc6b661433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>ABSORPTION</topic><topic>Animals</topic><topic>Anticarcinogenic Agents - metabolism</topic><topic>ANTINEOPLASTIC AGENTS</topic><topic>Biological and medical sciences</topic><topic>Caco-2 Cells</topic><topic>CELLS</topic><topic>Citrus - chemistry</topic><topic>CITRUS FRUITS</topic><topic>Flavones</topic><topic>FLAVONOIDS</topic><topic>Flavonoids - chemistry</topic><topic>Flavonoids - metabolism</topic><topic>Flavonoids - pharmacokinetics</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>IN VITRO EXPERIMENTATION</topic><topic>Intestinal Absorption</topic><topic>Intestinal Mucosa - metabolism</topic><topic>INTESTINES</topic><topic>Liver - metabolism</topic><topic>Luteolin</topic><topic>Medical sciences</topic><topic>METABOLISM</topic><topic>Molecular Structure</topic><topic>nobiletin</topic><topic>Pharmacognosy. 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(Kinki Univ., Higashiosaka, Osaka (Japan))</creatorcontrib><creatorcontrib>Kuwahara, S</creatorcontrib><creatorcontrib>Takahashi, Y</creatorcontrib><creatorcontrib>Ito, C</creatorcontrib><creatorcontrib>Furukawa, H</creatorcontrib><creatorcontrib>Juichi, M</creatorcontrib><creatorcontrib>Koshimizu, K</creatorcontrib><creatorcontrib>Ohigashi, H</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murakami, A. (Kinki Univ., Higashiosaka, Osaka (Japan))</au><au>Kuwahara, S</au><au>Takahashi, Y</au><au>Ito, C</au><au>Furukawa, H</au><au>Juichi, M</au><au>Koshimizu, K</au><au>Ohigashi, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid in citrus fruits</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2001-01-01</date><risdate>2001</risdate><volume>65</volume><issue>1</issue><spage>194</spage><epage>197</epage><pages>194-197</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>The polymethoxyflavonoid (PMF), nobiletin (NOB), specifically occurs in citrus fruits, and is currently believed to be a promising anti-inflammatory and anti-tumor promoting agent. 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| ispartof | Bioscience, biotechnology, and biochemistry, 2001-01, Vol.65 (1), p.194-197 |
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| source | J-STAGE Free; MEDLINE; Oxford University Press Journals All Titles (1996-Current); Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | ABSORPTION Animals Anticarcinogenic Agents - metabolism ANTINEOPLASTIC AGENTS Biological and medical sciences Caco-2 Cells CELLS Citrus - chemistry CITRUS FRUITS Flavones FLAVONOIDS Flavonoids - chemistry Flavonoids - metabolism Flavonoids - pharmacokinetics General pharmacology Humans IN VITRO EXPERIMENTATION Intestinal Absorption Intestinal Mucosa - metabolism INTESTINES Liver - metabolism Luteolin Medical sciences METABOLISM Molecular Structure nobiletin Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments rat liver S-9 mixture Rats |
| title | In vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid in citrus fruits |
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