Inhibition of telomerase activity by fungus metabolites, CRM646-A and thielavin B

We performed a screening program to identify telomerase inhibitors from our drug source obtained from fungus fermentations, and found that two compounds, CRM646-A and thielavin B, inhibited telomerase activity at doses of 3.2 and 32 μM, respectively. These compounds also inhibited the activity of vi...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2001-03, Vol.65 (3), p.651-653
Hauptverfasser:	Togashi, K. (Institute of Physical and Chemical Research, Wako, Saitama (Japan)), Ko, H.R, Ahn, J.S, Osada, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences CRM646-A Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology ENZYMES Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology FUNGI Humans Hydroxybenzoates - chemistry Hydroxybenzoates - pharmacology MANKIND Medical sciences METABOLITES METHODS Molecular Structure NEOPLASMS Pharmacology. Drug treatments reverse transcriptase screening telomerase Telomerase - antagonists & inhibitors Telomerase - metabolism TESTING thielavin B Transferases U937 Cells
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