Inhibitory Effect on the [alpha]-Glucosidase Reaction by the Aggregated State of Sulfoquinovosyldiacylglycerol

The inhibitory activity of aggregated SQDG toward the α-glucosidase reaction decreased with increasing turbidity of the SQDG suspension. Dideacylated derivatives of SQDG, sulfoquinovosylglycerol and sulfoquinovose, showed no inhibition toward the reaction. The expression of inhibition by the SQDG family would require a hydrophobic acyl group(s) to produce an aggregate and/or interact with a hydrophobic site in the enzyme.