Transformation of 7-(4-Hydroxyphenylacetamido)cephalosporanic Acid into a New Cephalosporin Antibiotic, 7-[1-Oxaspiro(2.5)octa-6-oxo-4, 7-diene-2-carboxamido]ceph-alosporanic Acid, by Laccase

Transformation of 7-(4-Hydroxyphenylacetamido)cephalosporanic Acid into a New Cephalosporin Antibiotic, 7-[1-Oxaspiro(2.5)octa-6-oxo-4, 7-diene-2-carboxamido]ceph-alosporanic Acid, by Laccase

7-(4-Hydroxyphenylacetamido)cephalosporanic acid (1) was transformed into 7-[1-oxaspiro(2.5)octa-6-oxo-4, 7-diene-2-carbox-amido]cephalosporanic acid (2) by laccase-catalyzed phenolic oxidation. 2 consisted of two diastereomers, named CXL-1 and CXL-2. CXL-2 was 10-30 times more active than CXL-1, al...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1993-08, Vol.57 (8), p.1387
Hauptverfasser: Agematu, Hitosi, Kominato, Kaichiro, Shibamoto, Norio, Yoshioka, Takeo, Nishida, Hiroshi, Okamoto, Rokuro, Shin, Takashi, Murao, Sawao
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 8
container_start_page 1387
container_title Bioscience, biotechnology, and biochemistry
container_volume 57
creator Agematu, Hitosi
Kominato, Kaichiro
Shibamoto, Norio
Yoshioka, Takeo
Nishida, Hiroshi
Okamoto, Rokuro
Shin, Takashi
Murao, Sawao
description 7-(4-Hydroxyphenylacetamido)cephalosporanic acid (1) was transformed into 7-[1-oxaspiro(2.5)octa-6-oxo-4, 7-diene-2-carbox-amido]cephalosporanic acid (2) by laccase-catalyzed phenolic oxidation. 2 consisted of two diastereomers, named CXL-1 and CXL-2. CXL-2 was 10-30 times more active than CXL-1, although less active than 1.
format Article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_1449396084</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3121592071</sourcerecordid><originalsourceid>FETCH-proquest_journals_14493960843</originalsourceid><addsrcrecordid>eNqNjc1Kw0AUhQdRMP68w4CbFnol00ySZlmK0oXopjuRcjOZ0Cnp3HFmisnT-WqmIgiuXF043zn3O2OJyGQJRSXLc5aklShgIXNxya5C2KfpGOQiYZ8bjza05A8YDVlOLS9hImE9NJ76we20HTpUOuLBNDRV2u2wo-BonBnFl8o03NhIHPmz_uCrX24sX9poakPRqNn49VXAS4_BGU-T-X0-JRURCqCeQJ54Y7TVMAeFvqb-2_d28sFf4YzXA39CpTDoG3bRYhf07c-9ZnePD5vVGpyn96MOcbuno7cj2gopq6wq0oXM_tf6AsjtZtI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1449396084</pqid></control><display><type>article</type><title>Transformation of 7-(4-Hydroxyphenylacetamido)cephalosporanic Acid into a New Cephalosporin Antibiotic, 7-[1-Oxaspiro(2.5)octa-6-oxo-4, 7-diene-2-carboxamido]ceph-alosporanic Acid, by Laccase</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>J-STAGE (Japan Science &amp; Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>Open Access Titles of Japan</source><source>Free Full-Text Journals in Chemistry</source><creator>Agematu, Hitosi ; Kominato, Kaichiro ; Shibamoto, Norio ; Yoshioka, Takeo ; Nishida, Hiroshi ; Okamoto, Rokuro ; Shin, Takashi ; Murao, Sawao</creator><creatorcontrib>Agematu, Hitosi ; Kominato, Kaichiro ; Shibamoto, Norio ; Yoshioka, Takeo ; Nishida, Hiroshi ; Okamoto, Rokuro ; Shin, Takashi ; Murao, Sawao</creatorcontrib><description>7-(4-Hydroxyphenylacetamido)cephalosporanic acid (1) was transformed into 7-[1-oxaspiro(2.5)octa-6-oxo-4, 7-diene-2-carbox-amido]cephalosporanic acid (2) by laccase-catalyzed phenolic oxidation. 2 consisted of two diastereomers, named CXL-1 and CXL-2. CXL-2 was 10-30 times more active than CXL-1, although less active than 1.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><language>eng</language><publisher>Tokyo: Oxford University Press</publisher><ispartof>Bioscience, biotechnology, and biochemistry, 1993-08, Vol.57 (8), p.1387</ispartof><rights>Copyright Japan Science and Technology Agency 1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Agematu, Hitosi</creatorcontrib><creatorcontrib>Kominato, Kaichiro</creatorcontrib><creatorcontrib>Shibamoto, Norio</creatorcontrib><creatorcontrib>Yoshioka, Takeo</creatorcontrib><creatorcontrib>Nishida, Hiroshi</creatorcontrib><creatorcontrib>Okamoto, Rokuro</creatorcontrib><creatorcontrib>Shin, Takashi</creatorcontrib><creatorcontrib>Murao, Sawao</creatorcontrib><title>Transformation of 7-(4-Hydroxyphenylacetamido)cephalosporanic Acid into a New Cephalosporin Antibiotic, 7-[1-Oxaspiro(2.5)octa-6-oxo-4, 7-diene-2-carboxamido]ceph-alosporanic Acid, by Laccase</title><title>Bioscience, biotechnology, and biochemistry</title><description>7-(4-Hydroxyphenylacetamido)cephalosporanic acid (1) was transformed into 7-[1-oxaspiro(2.5)octa-6-oxo-4, 7-diene-2-carbox-amido]cephalosporanic acid (2) by laccase-catalyzed phenolic oxidation. 2 consisted of two diastereomers, named CXL-1 and CXL-2. CXL-2 was 10-30 times more active than CXL-1, although less active than 1.</description><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqNjc1Kw0AUhQdRMP68w4CbFnol00ySZlmK0oXopjuRcjOZ0Cnp3HFmisnT-WqmIgiuXF043zn3O2OJyGQJRSXLc5aklShgIXNxya5C2KfpGOQiYZ8bjza05A8YDVlOLS9hImE9NJ76we20HTpUOuLBNDRV2u2wo-BonBnFl8o03NhIHPmz_uCrX24sX9poakPRqNn49VXAS4_BGU-T-X0-JRURCqCeQJ54Y7TVMAeFvqb-2_d28sFf4YzXA39CpTDoG3bRYhf07c-9ZnePD5vVGpyn96MOcbuno7cj2gopq6wq0oXM_tf6AsjtZtI</recordid><startdate>19930801</startdate><enddate>19930801</enddate><creator>Agematu, Hitosi</creator><creator>Kominato, Kaichiro</creator><creator>Shibamoto, Norio</creator><creator>Yoshioka, Takeo</creator><creator>Nishida, Hiroshi</creator><creator>Okamoto, Rokuro</creator><creator>Shin, Takashi</creator><creator>Murao, Sawao</creator><general>Oxford University Press</general><scope/></search><sort><creationdate>19930801</creationdate><title>Transformation of 7-(4-Hydroxyphenylacetamido)cephalosporanic Acid into a New Cephalosporin Antibiotic, 7-[1-Oxaspiro(2.5)octa-6-oxo-4, 7-diene-2-carboxamido]ceph-alosporanic Acid, by Laccase</title><author>Agematu, Hitosi ; Kominato, Kaichiro ; Shibamoto, Norio ; Yoshioka, Takeo ; Nishida, Hiroshi ; Okamoto, Rokuro ; Shin, Takashi ; Murao, Sawao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_14493960843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agematu, Hitosi</creatorcontrib><creatorcontrib>Kominato, Kaichiro</creatorcontrib><creatorcontrib>Shibamoto, Norio</creatorcontrib><creatorcontrib>Yoshioka, Takeo</creatorcontrib><creatorcontrib>Nishida, Hiroshi</creatorcontrib><creatorcontrib>Okamoto, Rokuro</creatorcontrib><creatorcontrib>Shin, Takashi</creatorcontrib><creatorcontrib>Murao, Sawao</creatorcontrib><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agematu, Hitosi</au><au>Kominato, Kaichiro</au><au>Shibamoto, Norio</au><au>Yoshioka, Takeo</au><au>Nishida, Hiroshi</au><au>Okamoto, Rokuro</au><au>Shin, Takashi</au><au>Murao, Sawao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transformation of 7-(4-Hydroxyphenylacetamido)cephalosporanic Acid into a New Cephalosporin Antibiotic, 7-[1-Oxaspiro(2.5)octa-6-oxo-4, 7-diene-2-carboxamido]ceph-alosporanic Acid, by Laccase</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><date>1993-08-01</date><risdate>1993</risdate><volume>57</volume><issue>8</issue><spage>1387</spage><pages>1387-</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>7-(4-Hydroxyphenylacetamido)cephalosporanic acid (1) was transformed into 7-[1-oxaspiro(2.5)octa-6-oxo-4, 7-diene-2-carbox-amido]cephalosporanic acid (2) by laccase-catalyzed phenolic oxidation. 2 consisted of two diastereomers, named CXL-1 and CXL-2. CXL-2 was 10-30 times more active than CXL-1, although less active than 1.</abstract><cop>Tokyo</cop><pub>Oxford University Press</pub></addata></record>
fulltext fulltext
identifier ISSN: 0916-8451
ispartof Bioscience, biotechnology, and biochemistry, 1993-08, Vol.57 (8), p.1387
issn 0916-8451
1347-6947
language eng
recordid cdi_proquest_journals_1449396084
source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Open Access Titles of Japan; Free Full-Text Journals in Chemistry
title Transformation of 7-(4-Hydroxyphenylacetamido)cephalosporanic Acid into a New Cephalosporin Antibiotic, 7-[1-Oxaspiro(2.5)octa-6-oxo-4, 7-diene-2-carboxamido]ceph-alosporanic Acid, by Laccase
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T16%3A43%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Transformation%20of%207-(4-Hydroxyphenylacetamido)cephalosporanic%20Acid%20into%20a%20New%20Cephalosporin%20Antibiotic,%207-%5B1-Oxaspiro(2.5)octa-6-oxo-4,%207-diene-2-carboxamido%5Dceph-alosporanic%20Acid,%20by%20Laccase&rft.jtitle=Bioscience,%20biotechnology,%20and%20biochemistry&rft.au=Agematu,%20Hitosi&rft.date=1993-08-01&rft.volume=57&rft.issue=8&rft.spage=1387&rft.pages=1387-&rft.issn=0916-8451&rft.eissn=1347-6947&rft_id=info:doi/&rft_dat=%3Cproquest%3E3121592071%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1449396084&rft_id=info:pmid/&rfr_iscdi=true