Eupatilin with Heme Oxygenase-1-Inducing Ability Protects Cultured Feline Esophageal Epithelial Cells from Cell Damage Caused by Indomethacin

We previously reported that eupatilin (5,7-dihydroxy-3,4,6-trimethoxyflavone) extracted from Artemisia asiaitica, augmented the cellular antioxidant defense capacity through induction of the antioxidant protein heme oxygenase-1 (HO-1), thereby protecting ileal smooth muscle cells from nonsteroidal a...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2009/04/01, Vol.32(4), pp.589-596
Hauptverfasser:	Song, Hyun Ju, Shin, Chang Yell, Oh, Tae Young, Min, Young Sil, Park, Eon Sub, Sohn, Uy Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - toxicity Blotting, Western Cats Cell Survival - drug effects Cells, Cultured Culture Media, Serum-Free Enzyme Induction - drug effects Enzyme Inhibitors - pharmacology Epithelial Cells - drug effects esophageal epithelial cell Esophagus - cytology Esophagus - drug effects eupatilin Flavonoids - pharmacology heme oxygenase-1 Heme Oxygenase-1 - biosynthesis Immunohistochemistry Indicators and Reagents indomethacin Indomethacin - antagonists & inhibitors Indomethacin - toxicity Nuclear Proteins - metabolism Protective Agents Rats Rats, Sprague-Dawley
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