Silibinin Attenuates Mast Cell-Mediated Anaphylaxis-Like Reactions
Silibinin is known to have hepatoprotective, anti-carcinogenic and anti-inflammatory effects. However, roles of silibinin in the immediate-type allergic reactions (anaphylaxis) have not fully been investigated. In the present study, we have demonstrated that silibinin attenuated mast cell-mediated a...
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| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2009/05/01, Vol.32(5), pp.868-875 |
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| description | Silibinin is known to have hepatoprotective, anti-carcinogenic and anti-inflammatory effects. However, roles of silibinin in the immediate-type allergic reactions (anaphylaxis) have not fully been investigated. In the present study, we have demonstrated that silibinin attenuated mast cell-mediated anaphylaxis-like reactions involved in allergic diseases. Oral administration of silibinin inhibited compound 48/80-induced passive cutaneous anaphylaxis-like reaction in mice. Silibinin also attenuated anti-dinitrophenyl (DNP) immunoglobulin (Ig) E-mediated passive systemic and cutaneous anaphylaxis. Silibinin had no cytotoxicity on rat peritoneal mast cells (RPMC). Silibinin dose-dependently reduced histamine release from RPMC activated by compound 48/80 or anti-DNP IgE. Moreover, silibinin inhibited the secretion of pro-inflammatory cytokines, such as tumor necrosis factor-α and interleukin-6 in RPMC. Pretreatment of silibinin suppressed the antigen-stimulated calcium uptake and activation of nuclear factor-kappa B (NF-κB) in RPMC. Furthermore, silibinin increased the intracellular cAMP level. Increased cAMP, decreased calcium uptake and suppressed NF-κB activity might be involved in the inhibitory effect of silibinin on the secretory response. Our findings provide possibility that silibinin may serve as an effective therapeutic agent for allergic diseases. |
| doi_str_mv | 10.1248/bpb.32.868 |
| format | Article |
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However, roles of silibinin in the immediate-type allergic reactions (anaphylaxis) have not fully been investigated. In the present study, we have demonstrated that silibinin attenuated mast cell-mediated anaphylaxis-like reactions involved in allergic diseases. Oral administration of silibinin inhibited compound 48/80-induced passive cutaneous anaphylaxis-like reaction in mice. Silibinin also attenuated anti-dinitrophenyl (DNP) immunoglobulin (Ig) E-mediated passive systemic and cutaneous anaphylaxis. Silibinin had no cytotoxicity on rat peritoneal mast cells (RPMC). Silibinin dose-dependently reduced histamine release from RPMC activated by compound 48/80 or anti-DNP IgE. Moreover, silibinin inhibited the secretion of pro-inflammatory cytokines, such as tumor necrosis factor-α and interleukin-6 in RPMC. Pretreatment of silibinin suppressed the antigen-stimulated calcium uptake and activation of nuclear factor-kappa B (NF-κB) in RPMC. Furthermore, silibinin increased the intracellular cAMP level. Increased cAMP, decreased calcium uptake and suppressed NF-κB activity might be involved in the inhibitory effect of silibinin on the secretory response. Our findings provide possibility that silibinin may serve as an effective therapeutic agent for allergic diseases.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.32.868</identifier><identifier>PMID: 19420756</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Anaphylaxis - immunology ; Anaphylaxis - metabolism ; Anaphylaxis - prevention & control ; anaphylaxis-like reaction ; Animals ; Anti-Allergic Agents - administration & dosage ; Anti-Allergic Agents - pharmacology ; Anti-Allergic Agents - therapeutic use ; calcium ; Calcium - metabolism ; cAMP ; Cell Nucleus - drug effects ; Cell Nucleus - metabolism ; Cell Survival - drug effects ; Cells, Cultured ; Cytosol - drug effects ; Cytosol - metabolism ; Disease Models, Animal ; histamine ; Histamine Release - drug effects ; Interleukin-6 - immunology ; Interleukin-6 - metabolism ; Male ; mast cell ; Mast Cells - drug effects ; Mast Cells - metabolism ; Mice ; Mice, Inbred ICR ; NF-kappa B - metabolism ; Rats ; Rats, Sprague-Dawley ; silibinin ; Silybin ; Silymarin - administration & dosage ; Silymarin - pharmacology ; Silymarin - therapeutic use ; Tumor Necrosis Factor-alpha - immunology ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>Biological and Pharmaceutical Bulletin, 2009/05/01, Vol.32(5), pp.868-875</ispartof><rights>2009 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c685t-239ffe920e087441b6a6b2f5fc5d4e211e7ccb8fe964cb1301785ab403520e8f3</citedby><cites>FETCH-LOGICAL-c685t-239ffe920e087441b6a6b2f5fc5d4e211e7ccb8fe964cb1301785ab403520e8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19420756$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Yun Ho</creatorcontrib><creatorcontrib>Yan, Guang Hai</creatorcontrib><creatorcontrib>Department of Anatomy</creatorcontrib><creatorcontrib>Department of Anatomy and Histology and Embryology</creatorcontrib><creatorcontrib>Yanbian University School of Basic Medical Sciences</creatorcontrib><creatorcontrib>Chonbuk National University Medical School</creatorcontrib><title>Silibinin Attenuates Mast Cell-Mediated Anaphylaxis-Like Reactions</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Silibinin is known to have hepatoprotective, anti-carcinogenic and anti-inflammatory effects. However, roles of silibinin in the immediate-type allergic reactions (anaphylaxis) have not fully been investigated. In the present study, we have demonstrated that silibinin attenuated mast cell-mediated anaphylaxis-like reactions involved in allergic diseases. Oral administration of silibinin inhibited compound 48/80-induced passive cutaneous anaphylaxis-like reaction in mice. Silibinin also attenuated anti-dinitrophenyl (DNP) immunoglobulin (Ig) E-mediated passive systemic and cutaneous anaphylaxis. Silibinin had no cytotoxicity on rat peritoneal mast cells (RPMC). Silibinin dose-dependently reduced histamine release from RPMC activated by compound 48/80 or anti-DNP IgE. Moreover, silibinin inhibited the secretion of pro-inflammatory cytokines, such as tumor necrosis factor-α and interleukin-6 in RPMC. Pretreatment of silibinin suppressed the antigen-stimulated calcium uptake and activation of nuclear factor-kappa B (NF-κB) in RPMC. Furthermore, silibinin increased the intracellular cAMP level. Increased cAMP, decreased calcium uptake and suppressed NF-κB activity might be involved in the inhibitory effect of silibinin on the secretory response. Our findings provide possibility that silibinin may serve as an effective therapeutic agent for allergic diseases.</description><subject>Anaphylaxis - immunology</subject><subject>Anaphylaxis - metabolism</subject><subject>Anaphylaxis - prevention & control</subject><subject>anaphylaxis-like reaction</subject><subject>Animals</subject><subject>Anti-Allergic Agents - administration & dosage</subject><subject>Anti-Allergic Agents - pharmacology</subject><subject>Anti-Allergic Agents - therapeutic use</subject><subject>calcium</subject><subject>Calcium - metabolism</subject><subject>cAMP</subject><subject>Cell Nucleus - drug effects</subject><subject>Cell Nucleus - metabolism</subject><subject>Cell Survival - drug effects</subject><subject>Cells, Cultured</subject><subject>Cytosol - drug effects</subject><subject>Cytosol - metabolism</subject><subject>Disease Models, Animal</subject><subject>histamine</subject><subject>Histamine Release - drug effects</subject><subject>Interleukin-6 - immunology</subject><subject>Interleukin-6 - metabolism</subject><subject>Male</subject><subject>mast cell</subject><subject>Mast Cells - drug effects</subject><subject>Mast Cells - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>NF-kappa B - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>silibinin</subject><subject>Silybin</subject><subject>Silymarin - administration & dosage</subject><subject>Silymarin - pharmacology</subject><subject>Silymarin - therapeutic use</subject><subject>Tumor Necrosis Factor-alpha - immunology</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE9vEzEQxS0EomnhwgdAK3FD2jD-t2ufUIjagpSqUoGzZTuz1MH1hrUj0W9fl03pZUaa-c17o0fIOwpLyoT65PZuydlSdeoFWVAu-lYyKl-SBWiq2o5KdUJOc94BQA-MvyYnVAsGvewW5Mv3EIMLKaRmVQqmgy2YmyubS7PGGNsr3IY62jarZPe399H-DbndhN_Y3KD1JYwpvyGvBhszvj32M_Lz4vzH-mu7ub78tl5tWt8pWVrG9TCgZoCgeiGo62zn2CAHL7cCGaXYe-9URTrhHeVAeyWtE8BlvVEDPyMfZt39NP45YC5mNx6mVC0NFULznmmlK_Vxpvw05jzhYPZTuLPTvaFgHuMyNS7DmalxVfj9UfLg7nD7jB7zqcDFDNRt8DaOKYaEz8Y-9y6McTQMQBsAzkAaoMpAla-ll0xr8e-tz7PQLhf7C_872akEH_HpKTmXx-Onjb-1k8HEHwBeo5Gm</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Choi, Yun Ho</creator><creator>Yan, Guang Hai</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>20090501</creationdate><title>Silibinin Attenuates Mast Cell-Mediated Anaphylaxis-Like Reactions</title><author>Choi, Yun Ho ; Yan, Guang Hai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c685t-239ffe920e087441b6a6b2f5fc5d4e211e7ccb8fe964cb1301785ab403520e8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Anaphylaxis - immunology</topic><topic>Anaphylaxis - metabolism</topic><topic>Anaphylaxis - prevention & control</topic><topic>anaphylaxis-like reaction</topic><topic>Animals</topic><topic>Anti-Allergic Agents - administration & dosage</topic><topic>Anti-Allergic Agents - pharmacology</topic><topic>Anti-Allergic Agents - therapeutic use</topic><topic>calcium</topic><topic>Calcium - metabolism</topic><topic>cAMP</topic><topic>Cell Nucleus - drug effects</topic><topic>Cell Nucleus - metabolism</topic><topic>Cell Survival - drug effects</topic><topic>Cells, Cultured</topic><topic>Cytosol - drug effects</topic><topic>Cytosol - metabolism</topic><topic>Disease Models, Animal</topic><topic>histamine</topic><topic>Histamine Release - drug effects</topic><topic>Interleukin-6 - immunology</topic><topic>Interleukin-6 - metabolism</topic><topic>Male</topic><topic>mast cell</topic><topic>Mast Cells - drug effects</topic><topic>Mast Cells - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>NF-kappa B - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>silibinin</topic><topic>Silybin</topic><topic>Silymarin - administration & dosage</topic><topic>Silymarin - pharmacology</topic><topic>Silymarin - therapeutic use</topic><topic>Tumor Necrosis Factor-alpha - immunology</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Yun Ho</creatorcontrib><creatorcontrib>Yan, Guang Hai</creatorcontrib><creatorcontrib>Department of Anatomy</creatorcontrib><creatorcontrib>Department of Anatomy and Histology and Embryology</creatorcontrib><creatorcontrib>Yanbian University School of Basic Medical Sciences</creatorcontrib><creatorcontrib>Chonbuk National University Medical School</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biological & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Yun Ho</au><au>Yan, Guang Hai</au><aucorp>Department of Anatomy</aucorp><aucorp>Department of Anatomy and Histology and Embryology</aucorp><aucorp>Yanbian University School of Basic Medical Sciences</aucorp><aucorp>Chonbuk National University Medical School</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Silibinin Attenuates Mast Cell-Mediated Anaphylaxis-Like Reactions</atitle><jtitle>Biological & Pharmaceutical Bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>32</volume><issue>5</issue><spage>868</spage><epage>875</epage><pages>868-875</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Silibinin is known to have hepatoprotective, anti-carcinogenic and anti-inflammatory effects. However, roles of silibinin in the immediate-type allergic reactions (anaphylaxis) have not fully been investigated. In the present study, we have demonstrated that silibinin attenuated mast cell-mediated anaphylaxis-like reactions involved in allergic diseases. Oral administration of silibinin inhibited compound 48/80-induced passive cutaneous anaphylaxis-like reaction in mice. Silibinin also attenuated anti-dinitrophenyl (DNP) immunoglobulin (Ig) E-mediated passive systemic and cutaneous anaphylaxis. Silibinin had no cytotoxicity on rat peritoneal mast cells (RPMC). Silibinin dose-dependently reduced histamine release from RPMC activated by compound 48/80 or anti-DNP IgE. Moreover, silibinin inhibited the secretion of pro-inflammatory cytokines, such as tumor necrosis factor-α and interleukin-6 in RPMC. Pretreatment of silibinin suppressed the antigen-stimulated calcium uptake and activation of nuclear factor-kappa B (NF-κB) in RPMC. Furthermore, silibinin increased the intracellular cAMP level. Increased cAMP, decreased calcium uptake and suppressed NF-κB activity might be involved in the inhibitory effect of silibinin on the secretory response. Our findings provide possibility that silibinin may serve as an effective therapeutic agent for allergic diseases.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>19420756</pmid><doi>10.1248/bpb.32.868</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anaphylaxis - immunology Anaphylaxis - metabolism Anaphylaxis - prevention & control anaphylaxis-like reaction Animals Anti-Allergic Agents - administration & dosage Anti-Allergic Agents - pharmacology Anti-Allergic Agents - therapeutic use calcium Calcium - metabolism cAMP Cell Nucleus - drug effects Cell Nucleus - metabolism Cell Survival - drug effects Cells, Cultured Cytosol - drug effects Cytosol - metabolism Disease Models, Animal histamine Histamine Release - drug effects Interleukin-6 - immunology Interleukin-6 - metabolism Male mast cell Mast Cells - drug effects Mast Cells - metabolism Mice Mice, Inbred ICR NF-kappa B - metabolism Rats Rats, Sprague-Dawley silibinin Silybin Silymarin - administration & dosage Silymarin - pharmacology Silymarin - therapeutic use Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism |
| title | Silibinin Attenuates Mast Cell-Mediated Anaphylaxis-Like Reactions |
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