Effects of Topical Application of Tacrolimus on Acute Itch-Associated Responses in Mice

Using mice, we examined whether the topical application of tacrolimus would produce an acute anti-pruritic effect. An itch-related response, scratching, was elicited by intradermal injections of mosquito allergen (10 μg/site) in sensitized mice and SLIGRL-NH2 (protease-activated receptor-2 agonist,...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2008/04/01, Vol.31(4), pp.752-754
Hauptverfasser:	Nakano, Tasuku, Andoh, Tsugunobu, Tayama, Manabu, Kosaka, Mayumi, Lee, Jung-Bum, Kuraishi, Yasushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Aedes Animals Antipruritics Behavior, Animal Capsaicin Female Histamine Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - pharmacology itch Male Mice Mice, Inbred ICR mosquito allergy protease-activated receptor-2 Pruritus - chemically induced Pruritus - drug therapy Pruritus - psychology Serotonin Substance P tacrolimus Tacrolimus - administration & dosage Tacrolimus - pharmacology
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